Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-2 dong, Songpa-gu, Seoul 138-736. Korea.
Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong. Korea.
Curr Stem Cell Res Ther. 2017;12(7):535-543. doi: 10.2174/1574888X12666170829161058.
Adipose-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs) within the stromal vascular fraction of subcutaneous adipose tissue. ADSCs secrete growth factors and other proteins, and have been used to regenerate skin with satisfactory results.
This review focuses on the effect of ADSCs and their secretory factors on the stimulation of hair growth in vitro, ex vivo and in vivo.
The conditioned media of ADSCs (ADSC-CM) increases the proliferation rate of human follicular cells. ADSCs-derived proteins improve hair growth and protect human dermal papilla cells against cytotoxic injury caused by androgen and reactive oxygen species. Moreover, ADSC-CM induces the anagen phase and promotes hair growth in mice, and enhances the elongation of hair shafts in ex vivo human hair organ cultures.
ADSC-CM promotes hair growth in vitro, ex vivo, and in vivo. Given that ADSCs are one of the most accessible sources of MSCs, ADSC-derived proteins may be feasible clinical therapeutic agents for the treatment of hair loss.
脂肪来源干细胞（ADSCs）是存在于皮下脂肪组织基质血管部分的间充质干细胞（MSCs）。ADSCs 分泌生长因子和其他蛋白质，已被用于再生皮肤，取得了令人满意的效果。
本综述重点关注 ADSCs 及其分泌因子对体外、离体和体内毛发生长刺激的作用。
ADSCs 的条件培养基（ADSC-CM）增加了人毛囊细胞的增殖率。ADSC 衍生蛋白可改善毛发生长，并保护人真皮乳头细胞免受雄激素和活性氧引起的细胞毒性损伤。此外，ADSC-CM 诱导毛囊进入生长期并促进小鼠毛发生长，以及增强离体人毛发生长器官培养中毛发的伸长。
ADSC-CM 促进体外、离体和体内的毛发生长。鉴于 ADSCs 是 MSC 最容易获得的来源之一，ADSC 衍生蛋白可能是治疗脱发的可行临床治疗药物。
