Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Sci Rep. 2023 Mar 10;13(1):4037. doi: 10.1038/s41598-022-23827-0.
So far, few studies have examined the effect of salt taste receptors genetic variation on dietary intake in the Iranian population. We aimed to evaluate associations between single nucleotide polymorphisms (SNPs) in salt taste receptors' genes with dietary salt intake and blood pressure. A cross-sectional study was carried out among 116 randomly selected healthy adults aged ≥ 18 in Isfahan, Iran. Participants underwent sodium intake determination by 24-h urine collection, as well as dietary assessment by semi-quantitative food frequency questionnaire and blood pressure measurement. Whole blood was collected to extract DNA and genotype of SNP rs239345 in SCNN1B and rs224534, rs4790151 and rs8065080 in TRPV1 gene. Sodium consumption and diastolic blood pressure were significantly higher in carriers of the A-allele in rs239345 compared to subjects with the TT genotype (4808.4 ± 824.4 mg/day vs. 4043.5 ± 989.3 mg/day; P = 0.004) and 83.6 ± 8.5 mmHg vs. 77.3 ± 7.3 mmHg; P = 0.011), respectively. The level of sodium intake was lower in the TT genotype of TRPV1 (rs224534) than the CC genotype (3767.0 ± 713.7 mg/day vs. 4633.3 ± 793.5 mg/day; P = 0.012). We could not find any association between genotypes of all SNPs with systolic blood pressure as well as genotypes of rs224534, rs4790151 and rs8065080 with diastolic blood pressure. Genetic variations can relate with salt intake and consequently may associate with hypertension and finally cardiovascular disease risk in the Iranian population.
到目前为止，很少有研究检查盐味觉受体基因遗传变异对伊朗人群饮食摄入的影响。我们旨在评估盐味觉受体基因中的单核苷酸多态性（SNP）与膳食盐摄入量和血压之间的关联。在伊朗伊斯法罕随机选择了 116 名年龄≥18 岁的健康成年人进行了一项横断面研究。参与者通过 24 小时尿液收集来确定钠摄入量，通过半定量食物频率问卷和血压测量来评估饮食，并采集全血提取 SNP rs239345 在 SCNN1B 和 rs224534、rs4790151 和 rs8065080 在 TRPV1 基因中的基因型。与 TT 基因型相比，rs239345 中的 A 等位基因携带者的钠摄入量和舒张压显著更高（4808.4 ± 824.4 mg/天 vs. 4043.5 ± 989.3 mg/天；P=0.004）和 83.6 ± 8.5 mmHg vs. 77.3 ± 7.3 mmHg；P=0.011）。与 CC 基因型相比，TRPV1（rs224534）的 TT 基因型的钠摄入量较低（3767.0 ± 713.7 mg/天 vs. 4633.3 ± 793.5 mg/天；P=0.012）。我们没有发现所有 SNP 的基因型与收缩压以及 rs224534、rs4790151 和 rs8065080 的基因型与舒张压之间存在任何关联。遗传变异与盐摄入量有关，因此可能与伊朗人群的高血压和心血管疾病风险有关。
