Krasnovskaia I A, Sheĭbak T V, Polenov A L
Biull Eksp Biol Med. 1987 Dec;104(12):666-9.
Male Wistar rats were hypophysectomized 7 days (group 1) and 4-7 weeks (group II) before exposure to hypothermia (4 degrees C for 1 1/2 h). The hypophysectomized rats from group I were devoid of both the posterior lobe and the adenohypophysis, while the rats from group II had the posterior hypophysis but not the adenohypophysis regenerated. A decreased arginine-vasopressin (AVP) blood level in group I (32%) and a very high level of AVP in group II (311%, P less than 0.05) was determined by RIA. The exposure to hypothermia did not influence the AVP plasma level. The thyroid hypofunction was revealed morphometrically in both hypophysectomized groups. Nevertheless, cooling stimulated the thyroid glands in rats of both experimental groups, like it was in the control. Thus, there is no evidence that thyroid gland reaction to hypothermia is affected by AVP. Cooling caused an increase of corticosteroid blood and adrenal cortex content in nonoperated control rats as well as in group II, but not in group I of experimental animals. Hence, it may be assumed that when the adenohypophysis is ablated, a high AVP blood level is necessary to realize the adrenal cortex response to hypothermia.
雄性Wistar大鼠在暴露于低温环境（4℃，持续1.5小时）前7天（第1组）和4 - 7周（第II组）接受垂体切除。第1组的垂体切除大鼠的垂体后叶和腺垂体均缺失，而第II组的大鼠垂体后叶存在但腺垂体未再生。通过放射免疫分析法测定，第1组精氨酸加压素（AVP）血水平降低（32%），第II组AVP水平非常高（311%，P < 0.05）。暴露于低温环境未影响AVP血浆水平。在两个垂体切除组中均通过形态计量学揭示了甲状腺功能减退。然而，低温刺激了两个实验组大鼠的甲状腺，与对照组情况相同。因此，没有证据表明甲状腺对低温的反应受AVP影响。低温导致未手术的对照大鼠以及第II组实验动物的血皮质类固醇和肾上腺皮质含量增加，但第I组实验动物未出现这种情况。因此，可以假定当腺垂体被切除时，高AVP血水平对于实现肾上腺皮质对低温的反应是必要的。
