Petkova M, Popova N, Kolarova R
Eksp Med Morfol. 1977;16(4):194-7.
The authors examined dynamically the arterial pressure and plasma activity of 11-hydroxycorticosteroids in two groups of rats with pure hypertension and with hypertension on the background of beta-adrenergic activity. There was an elevation of arterial pressure in both groups, less manifested in the rats, treated with beta blocker. The values after six months were equally high in both groups. The content of 11-hydroxycorticosteroids was increased with a maximum at the sixth month. The authors make an inference that beta blocker-obsidan lowers blood pressure, but does not affect the level of 11-hydroxycorticosteroidids in plasma.
作者动态检测了两组大鼠的动脉血压及血浆11-羟皮质类固醇活性，一组为单纯高血压大鼠，另一组为存在β-肾上腺素能活性背景下的高血压大鼠。两组大鼠的动脉血压均升高，而使用β受体阻滞剂治疗的大鼠血压升高程度较轻。六个月后两组的血压值同样高。11-羟皮质类固醇的含量增加，在第六个月达到最高值。作者推断，β受体阻滞剂——奥昔坦可降低血压，但不影响血浆中11-羟皮质类固醇的水平。
