Grek O R, Sharapov V I, Sokirchenko I A, Shkurupiĭ V A
Biull Eksp Biol Med. 1987 Dec;104(12):669-71.
The experiments on rats have shown that alpha-tocopherol and lidocaine pretreatment leads to a decrease in the level of ischemic cell necrosis in the liver. The volume of cell necrosis in the liver was significantly decreased (more than threefold) in the case of drug pretreatment. The combination of alpha-tocopherol with lidocaine fully prevented the decrease in N-dimethylation of amidopyrine and cytochrome P-450 and b5 concentration, and the development of destructive alterations of cytoplasmic reticulum in the unaffected rat hepatocytes. alpha-Tocopherol and lidocaine pretreatment was effective for the retention of the depression of microsomal monooxygenases by phenobarbital in remote periods after acute hepatic ischemia.
对大鼠的实验表明，α-生育酚和利多卡因预处理可使肝脏中缺血性细胞坏死水平降低。在药物预处理的情况下，肝脏中细胞坏死的体积显著减少（超过三倍）。α-生育酚与利多卡因的组合完全防止了氨基比林N-甲基化的降低以及细胞色素P-450和b5浓度的降低，以及未受影响的大鼠肝细胞中细胞质内质网的破坏性改变的发展。α-生育酚和利多卡因预处理对于在急性肝缺血后的远期保留苯巴比妥对微粒体单加氧酶的抑制作用是有效的。
