[The effect of alpha-tocopherol and lidocaine on the structural-functional rearrangement of liver endoplasmic reticulum membranes after induction with phenobarbital in the postischemic period]. - Suppr | 超能文献

[The effect of alpha-tocopherol and lidocaine on the structural-functional rearrangement of liver endoplasmic reticulum membranes after induction with phenobarbital in the postischemic period].

作者信息

Sharapov V I, Grek O R, Zykov A A

出版信息

Vopr Med Khim. 1990 Mar-Apr;36(2):14-8.

Abstract

Inhibition of an increase in total content of unsaturated fatty acids in microsomal lipids induced by phenobarbital, alterations of parameters of the fluorescent probe 1,8-ANS-binding with membranes as well as restrictions in induction of liver microsomal monooxygenase enzymatic system were detected during postischemic period after total liver tissue ischemia. Preadministration of alpha-tocopherol and lidocaine prevented distinctly the structure-functional alterations induced by phenobarbital in liver microsomal membranes during postischemic period. Possible factors responsible for limitations of the phenobarbital inducing effect during postischemic period are discussed.

摘要

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