Khodarev N N, Volgina V V, Aleksandrova S S, Votrin I I
Biull Eksp Biol Med. 1987 Dec;104(12):713-6.
Endo-DNAse (mostly Ca/Mg-dependent endonuclease) activity was studied in extracts of lymphocyte cellular nuclei from the spleen and thymus of mice upon their immunization with sheep red blood cells. Endo-DNAses were detected by their action on super-stranded DNA pBR 322. It has been established that endo-DNAse activity considerably changes in the course of immune response. The changes start in the early (induction) phase of immune response, are characterized by certain regularities and are distinct in thymus and spleen lymphocytes. It is assumed that endo-DNAses of lymphocyte cellular nuclei are involved in antigen-dependent lymphocyte differentiation.
在用绵羊红细胞免疫小鼠后，对其脾脏和胸腺淋巴细胞细胞核提取物中的内切脱氧核糖核酸酶（主要是钙/镁依赖性内切核酸酶）活性进行了研究。通过内切脱氧核糖核酸酶对超螺旋DNA pBR 322的作用来检测它们。已经确定，内切脱氧核糖核酸酶活性在免疫反应过程中会发生显著变化。这些变化始于免疫反应的早期（诱导）阶段，具有一定的规律性，并且在胸腺和脾脏淋巴细胞中有所不同。据推测，淋巴细胞细胞核的内切脱氧核糖核酸酶参与了抗原依赖性淋巴细胞的分化。
