Avan Razieh, Sahebnasagh Adeleh, Hashemi Javad, Monajati Mahila, Faramarzi Fatemeh, Henney Neil C, Montecucco Fabrizio, Jamialahmadi Tannaz, Sahebkar Amirhossein
Department of Clinical Pharmacy, Medical Toxicology and Drug Abuse Research Center (MTDRC), School of Pharmacy, Birjand University of Medical Sciences, Birjand 9717853577, Iran.
Clinical Research Center, Department of Internal Medicine, North Khorasan University of Medical Sciences, Bojnurd 9453155166, Iran.
Life (Basel). 2021 Dec 8;11(12):1365. doi: 10.3390/life11121365.
Statins are widely accepted as first-choice agents for the prevention of lipid-related cardiovascular diseases. These drugs have both anti-inflammatory and anti-oxidant properties, which may also make them effective as potential treatment marked by perturbations in these pathways, such as some neuropsychiatric disorders. In this narrative review, we have investigated the effects of statin therapy in individuals suffering from major depressive disorder (MDD), schizophrenia, anxiety, obsessive-compulsive disorder (OCD), bipolar disorder (BD), delirium, and autism spectrum disorders using a broad online search of electronic databases. We also explored the adverse effects of these drugs to obtain insights into the benefits and risks associated with their use in the treatment of these disorders. Lipophilic statins (including simvastatin) because of better brain penetrance may have greater protective effects against MDD and schizophrenia. The significant positive effects of statins in the treatment of anxiety disorders without any serious adverse side effects were shown in numerous studies. In OCD, BD, and delirium, limitations, and contradictions in the available data make it difficult to draw conclusions on any positive effect of statins. The positive effects of simvastatin in autism disorders have been evaluated in only a small number of clinical trials. Although some studies showed positive effect of statins in some neuropsychiatric disorders, further prospective studies are needed to confirm this and define the most effective doses and treatment durations.
他汀类药物被广泛认为是预防脂质相关心血管疾病的首选药物。这些药物具有抗炎和抗氧化特性，这也可能使它们作为潜在治疗药物有效，这些潜在治疗以这些途径的紊乱为特征，比如一些神经精神疾病。在这篇叙述性综述中，我们通过广泛在线检索电子数据库，研究了他汀类药物治疗对患有重度抑郁症（MDD）、精神分裂症、焦虑症、强迫症（OCD）、双相情感障碍（BD）、谵妄和自闭症谱系障碍患者的影响。我们还探讨了这些药物的不良反应，以深入了解其在治疗这些疾病时的益处和风险。亲脂性他汀类药物（包括辛伐他汀）由于具有更好的脑渗透性，可能对MDD和精神分裂症具有更大的保护作用。众多研究表明，他汀类药物在治疗焦虑症方面具有显著的积极效果，且无任何严重不良副作用。在OCD、BD和谵妄方面，现有数据的局限性和矛盾使得难以就他汀类药物的任何积极作用得出结论。辛伐他汀在自闭症谱系障碍中的积极作用仅在少数临床试验中得到评估。尽管一些研究表明他汀类药物在某些神经精神疾病中具有积极作用，但仍需要进一步的前瞻性研究来证实这一点，并确定最有效的剂量和治疗持续时间。
