来自巴西米纳斯吉拉斯州欧鲁普雷图的蕨菜（蕨属）在大鼠体内诱发肿瘤。

Induction of tumors in rats by bracken fern (Pteridium aquilinum) from Ouro Preto (Minas Gerais, Brazil).

Santos R C, Brasileiro-Filho G, Hojo E S

Departamento de Nutrição, Escola de Farmácia, Universidade Federal de Ouro Preto, MG, Brasil.

Braz J Med Biol Res. 1987;20(1):73-7.

Abstract

The possible carcinogenicity of bracken fern (Pteridium aquilinum, common name: "Broto de Samambaia") which is used as food by the population of Ouro Preto (Minas Gerais, Brazil) and neighboring areas, was studied in rats. 2. Fifteen (6 female and 9 male) 45-day old Wistar rats were fed a diet containing dried bracken fern (5%, w/w) for up to 70 weeks. After death or sacrifice, the animals were carefully examined for tumors in the gastrointestinal tract, bladder, lungs, liver, and kidneys. 3. All experimental animals showed gastrointestinal tract tumors which were located mainly in the ileum. Most of the tumors were malignant lesions (adenocarcinomas and sarcomas), although benign adenomas were also present. One animal developed a lymphoma and none showed vesical tumors. 4. No tumors were detected in 11 control rats (5 female and 6 male). 5. These data clearly demonstrate that Pteridium aquilinum is carcinogenic for rats.

摘要

对蕨菜（蕨属，俗名：“巴西铁角蕨”）的潜在致癌性进行了大鼠研究，蕨菜被巴西米纳斯吉拉斯州欧鲁普雷图及周边地区的居民用作食物。2. 15只（6只雌性和9只雄性）45日龄的Wistar大鼠被喂食含5%（w/w）干蕨菜的饲料，持续70周。在动物死亡或处死后，仔细检查其胃肠道、膀胱、肺、肝和肾中的肿瘤。3. 所有实验动物均出现胃肠道肿瘤，主要位于回肠。大多数肿瘤为恶性病变（腺癌和肉瘤），不过也有良性腺瘤。1只动物发生淋巴瘤，未发现膀胱肿瘤。4. 11只对照大鼠（5只雌性和6只雄性）未检测到肿瘤。5. 这些数据清楚地表明，蕨菜对大鼠具有致癌性。