Kohri K, Takada M, Katoh Y, Kataoka K, Iguchi M, Yachiku S, Kurita T
Department of Urology, Kinki University, Osaka, Japan.
Br J Urol. 1987 Jun;59(6):503-7. doi: 10.1111/j.1464-410x.1987.tb04863.x.
We have investigated the composition of plasma and urine in patients with recurrent calcium calculi treated with allopurinol alone, thiazide alone, and both agents together for more than 18 months, and compared the results with those of patients receiving no treatment. In patients treated with allopurinol, both plasma and urinary uric acid were decreased, and plasma parathyroid hormone (PTH) and urinary calcium were increased between 1 and 2 years after treatment. In patients treated with thiazide, plasma calcium was decreased 3 months after treatment but then increased gradually, although the pre-treatment level was not reached. Urinary calcium was decreased 3 months after treatment but returned to pre-treatment levels at 6 and 12 months. Plasma PTH was gradually increased. In patients treated with both allopurinol and thiazide, plasma and urinary uric acid, plasma potassium and urinary calcium were decreased during treatment. Plasma PTH increased gradually during treatment. In patients receiving no treatment, the composition of plasma and urine did not alter during follow-up. The reasons for the changes in urinary calcium and plasma PTH have been discussed.
我们研究了单独使用别嘌醇、单独使用噻嗪类药物以及两者联合使用超过18个月治疗复发性钙结石患者的血浆和尿液成分，并将结果与未接受治疗的患者进行了比较。在接受别嘌醇治疗的患者中，治疗1至2年后，血浆和尿尿酸均降低，血浆甲状旁腺激素（PTH）和尿钙升高。在接受噻嗪类药物治疗的患者中，治疗3个月后血浆钙降低，但随后逐渐升高，尽管未达到治疗前水平。治疗3个月后尿钙降低，但在6个月和12个月时恢复到治疗前水平。血浆PTH逐渐升高。在同时接受别嘌醇和噻嗪类药物治疗的患者中，治疗期间血浆和尿尿酸、血浆钾和尿钙均降低。治疗期间血浆PTH逐渐升高。在未接受治疗的患者中，随访期间血浆和尿液成分未发生改变。已对尿钙和血浆PTH变化的原因进行了讨论。
