mA 修饰在 B 细胞发育和 B 细胞相关疾病中的作用。
The Role of mA Modifications in B-Cell Development and B-Cell-Related Diseases.
机构信息
Beijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
NHC Key Laboratory of Human Disease Comparative Medicine, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China.
出版信息
Int J Mol Sci. 2023 Mar 1;24(5):4721. doi: 10.3390/ijms24054721.
B cells are a class of professional antigen-presenting cells that produce antibodies to mediate humoral immune response and participate in immune regulation. mA modification is the most common RNA modification in mRNA; it involves almost all aspects of RNA metabolism and can affect RNA splicing, translation, stability, etc. This review focuses on the B-cell maturation process as well as the role of three mA modification-related regulators-writer, eraser, and reader-in B-cell development and B-cell-related diseases. The identification of genes and modifiers that contribute to immune deficiency may shed light on regulatory requirements for normal B-cell development and the underlying mechanism of some common diseases.
B 细胞是一类专业的抗原呈递细胞，能够产生抗体来介导体液免疫应答并参与免疫调节。m6A 修饰是 mRNA 中最常见的 RNA 修饰；它几乎涉及 RNA 代谢的所有方面，可影响 RNA 剪接、翻译、稳定性等。本综述重点关注 B 细胞成熟过程以及三个 m6A 修饰相关调控因子（writer、eraser 和 reader）在 B 细胞发育和 B 细胞相关疾病中的作用。鉴定出导致免疫缺陷的基因和修饰因子，可能有助于揭示正常 B 细胞发育的调控需求和某些常见疾病的潜在机制。
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