源自农业废弃物的锌掺杂单相和双相磷酸钙材料及其潜在的生物医学应用：第一部分
Zn-doped Mono- and Biphasic Calcium Phosphate Materials Derived from Agriculture Waste and Their Potential Biomedical Applications: Part I.
作者信息
Kalbarczyk Marta, Szcześ Aleksandra, Belcarz Anna, Kazimierczak Paulina, May Zoltan
机构信息
Department of Interfacial Phenomena, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Skłodowska University, 20-031 Lublin, Poland.
Department of Electrical Engineering, Lublin University of Technology, 20-618 Lublin, Poland.
出版信息
Materials (Basel). 2023 Feb 28;16(5):1971. doi: 10.3390/ma16051971.
In this study, calcium phosphate materials were obtained via a simple, eco-friendly wet synthesis method using hen eggshells as a calcium source. It was shown that Zn ions were successfully incorporated into hydroxyapatite (HA). The obtained ceramic composition depends on the zinc content. When doped with 10 mol % of Zn, in addition to HA and Zn-doped HA, DCPD (dicalcium phosphate dihydrate) appeared and its content increased with the increase in Zn concentration. All doped HA materials exhibited antimicrobial activity against and . Nevertheless, fabricated samples significantly decreased preosteoblast (MC3T3-E1 Subclone 4) viability in vitro, exerting a cytotoxic effect which probably resulted from their high ionic reactivity.
在本研究中，通过一种简单、环保的湿合成方法，以鸡蛋壳作为钙源制备了磷酸钙材料。结果表明，锌离子成功掺入到羟基磷灰石（HA）中。所得陶瓷组合物取决于锌含量。当掺杂10摩尔%的锌时，除了HA和锌掺杂的HA外，还出现了二水磷酸二钙（DCPD），其含量随锌浓度的增加而增加。所有掺杂的HA材料均表现出对[具体微生物1]和[具体微生物2]的抗菌活性。然而，制备的样品在体外显著降低了前成骨细胞（MC3T3-E1亚克隆4）的活力，产生了细胞毒性作用，这可能是由于它们的高离子反应性所致。
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