Geng Zhen, Cheng You, Ma Lili, Li Zhaoyang, Cui Zhenduo, Zhu Shengli, Liang Yanqin, Liu Yunde, Bao Huijing, Li Xue, Yang Xianjin
1 Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering, Tianjin University, Tianjin, China.
2 School of Laboratory Medicine, Tianjin Medical University, Tianjin, China.
J Biomater Appl. 2018 Feb;32(7):896-905. doi: 10.1177/0885328217748124. Epub 2017 Dec 17.
The fabrication and application of bioactive hydroxyapatite has always been a research hot spot in the fields of orthopaedics. Now it is common to use calcium (Ca) salt as Ca source to synthesise hydroxyapatite. And egg shell could be another promising raw material as Ca source, which is not only economical but also biogenic. In this study, egg shell (ES)-hydroxyapatite was prepared by using egg shells via hydrothermal method. Furthermore, ES-Sr hydroxyapatite was synthesized by incorporation of bioactive element strontium (Sr) into ES-hydroxyapatite. The in vitro experiment showed that compared with hydroxyapatite, ES-hydroxyapatite showed better biological performances, which could be attributed to the trace elements in egg shell, such as magnesium (Mg). And the incorporation of Sr could further enhance the bioactivity. These results indicated that apatite with high biological activity, which had great application prospects in orthopedics, could be produced by egg shells and the incorporation of Sr.
生物活性羟基磷灰石的制备与应用一直是骨科领域的研究热点。目前，常用钙（Ca）盐作为钙源来合成羟基磷灰石。而蛋壳作为另一种有前景的钙源原料，不仅经济实惠而且具有生物源性。在本研究中，通过水热法利用蛋壳制备了蛋壳（ES）-羟基磷灰石。此外，通过将生物活性元素锶（Sr）掺入ES-羟基磷灰石中合成了ES-Sr羟基磷灰石。体外实验表明，与羟基磷灰石相比，ES-羟基磷灰石表现出更好的生物学性能，这可能归因于蛋壳中的微量元素，如镁（Mg）。而掺入Sr可进一步增强生物活性。这些结果表明，蛋壳及掺入Sr能够制备出具有高生物活性的磷灰石，在骨科领域具有广阔的应用前景。
