Huston J P, Kiefer S, Buscher W, Muñoz C
Institute of Physiological Psychology, University of Düsseldorf, F.R.G.
Brain Res. 1987 Dec 8;436(1):1-8. doi: 10.1016/0006-8993(87)91549-6.
Electrical self-stimulation in the lateral hypothalamus of both hemispheres was recorded in 14 rats before and after administration of a unilateral ibotenic acid lesion of the cell bodies in the region of the lateral preoptic area. A significant decrease in the rate of self-stimulation at each of two stimulation intensities was found when the electrode was placed in the hemisphere in which the ibotenic acid lesion was made. This decrease remained constant over 21 days of testing. No changes were detected in rate of self-stimulation in the intact contralateral hemisphere. These results provide evidence for a role in lateral hypothalamic self-stimulation of intrinsic neurons located in the region of the lateral preoptic area.
在14只大鼠中，记录了双侧下丘脑外侧的电自我刺激情况，这些大鼠在单侧注射鹅膏蕈氨酸损毁视前区外侧区域的细胞体之前和之后均进行了记录。当电极置于注射鹅膏蕈氨酸造成损毁的半球时，发现在两种刺激强度下，自我刺激速率均显著降低。在21天的测试过程中，这种降低保持不变。在完整的对侧半球中，未检测到自我刺激速率的变化。这些结果为视前区外侧区域的内在神经元在下丘脑外侧自我刺激中发挥作用提供了证据。
