应用姜黄素衍生物作为生物基增塑剂和光增敏剂的光抗菌聚氯乙烯薄膜。

CQC Department of Chemistry, University of Coimbra, Rua Larga, 3004-535 Coimbra, Portugal.

São Carlos Institute of Physics, University of São Paulo, São Carlos 13566-590, Brazil.

Molecules. 2023 Feb 27;28(5):2209. doi: 10.3390/molecules28052209.

Herein we describe the design of natural curcumin ester and ether derivatives and their application as potential bioplasticizers, to prepare photosensitive phthalate-free PVC-based materials. The preparation of PVC-based films incorporating several loadings of newly synthesized curcumin derivatives along with their standard solid-state characterization is also described. Remarkably, the plasticizing effect of the curcumin derivatives in the PVC material was found to be similar to that observed in previous PVC-phthalate materials. Finally, studies applying these new materials in the photoinactivation of planktonic cultures revealed a strong structure/activity correlation, with the photosensitive materials reaching up to 6 log CFU reduction at low irradiation intensities.

在这里，我们描述了天然姜黄素酯和醚衍生物的设计及其作为潜在的生物增塑剂的应用，以制备对光敏感的无邻苯二甲酸酯的基于聚氯乙烯的材料。还描述了含有几种新合成的姜黄素衍生物的负载量的基于聚氯乙烯的薄膜的制备及其标准的固态特性。值得注意的是，在聚氯乙烯材料中，姜黄素衍生物的增塑效果与先前观察到的聚氯乙烯-邻苯二甲酸酯材料中的效果相似。最后，应用这些新材料进行浮游生物培养物的光灭活研究表明，存在很强的结构/活性相关性，在低辐射强度下，光敏材料的减少量高达 6 个对数 CFU。