Department of Chemical and Geological Sciences, University of Cagliari, 09042 Monserrato, Italy.
Department of Chemical, Physical, Mathematical, and Natural Sciences, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
Molecules. 2023 Feb 28;28(5):2239. doi: 10.3390/molecules28052239.
The synthesis of nitrogen-based heterocycles has always been considered essential in developing pharmaceuticals in medicine and agriculture. This explains why various synthetic approaches have been proposed in recent decades. However performing as methods, they often imply harsh conditions or the employment of toxic solvents and dangerous reagents. Mechanochemistry is undoubtedly one of the most promising technologies currently used for reducing any possible environmental impact, addressing the worldwide interest in counteracting environmental pollution. Following this line, we propose a new mechanochemical protocol for synthesizing various heterocyclic classes by exploiting thiourea dioxide (TDO)'s reducing proprieties and electrophilic nature. Simultaneously exploiting the low cost of a component of the textile industry such as TDO and all the advantages brought by a green technique such as mechanochemistry, we plot a route towards a more sustainable and eco-friendly methodology for preparing heterocyclic moieties.
氮杂环的合成一直被认为是医药和农业领域开发药物的关键。这也解释了为什么近几十年来提出了各种合成方法。然而，作为方法，它们通常需要苛刻的条件或使用有毒溶剂和危险试剂。机械化学无疑是目前用于减少任何潜在环境影响的最有前途的技术之一，符合全球对抗环境污染的兴趣。基于这一思路，我们提出了一种新的机械化学方法，通过利用硫代二氧（TDO）的还原特性和亲电性，来合成各种杂环化合物。同时，利用纺织工业中 TDO 等低成本的组件以及机械化学等绿色技术带来的所有优势，我们为制备杂环部分制定了一条更加可持续和环保的方法。
