Key Laboratory of Drug Prevention and Control Technology of Zhejiang Province, Zhejiang Police College, Hangzhou 310053, China.
Molecules. 2023 Mar 2;28(5):2316. doi: 10.3390/molecules28052316.
Porous Au nanocrystals (Au NCs) have been widely used in catalysis, sensing, and biomedicine due to their excellent localized surface plasma resonance effect and a large number of active sites exposed by three-dimensional internal channels. Here, we developed a ligand-induced one-step method for the controllable preparation of mesoporous, microporous, and hierarchical porous Au NCs with internal 3D connecting channels. At 25 °C, using glutathione (GTH) as both a ligand and reducing agent combined with the Au precursor to form GTH-Au(I), and under the action of the reducing agent ascorbic acid, the Au precursor is reduced in situ to form a dandelion-like microporous structure assembled by Au rods. When cetyltrimethylammonium bromide (CTAB) and GTH are used as ligands, mesoporous Au NCs formed. When increasing the reaction temperature to 80 °C, hierarchical porous Au NCs with both microporous and mesoporous structures will be synthesized. We systematically explored the effect of reaction parameters on porous Au NCs and proposed possible reaction mechanisms. Furthermore, we compared the SERS-enhancing effect of Au NCs with three different pore structures. With hierarchical porous Au NCs as the SERS base, the detection limit for rhodamine 6G (R6G) reached 10 M.
多孔金纳米晶体（Au NCs）由于具有优异的局域表面等离子体共振效应和由三维内部通道暴露的大量活性位点，已广泛应用于催化、传感和生物医学领域。在这里，我们开发了一种配体诱导的一步法，可可控制备具有内部 3D 连接通道的介孔、微孔和分级多孔 Au NCs。在 25°C 下，使用谷胱甘肽（GTH）作为配体和还原剂与 Au 前体结合形成 GTH-Au(I)，并在还原剂抗坏血酸的作用下，Au 前体原位还原形成由 Au 棒组装的蒲公英状微孔结构。当使用十六烷基三甲基溴化铵（CTAB）和 GTH 作为配体时，形成介孔 Au NCs。当反应温度升高到 80°C 时，会合成具有微孔和介孔结构的分级多孔 Au NCs。我们系统地研究了反应参数对多孔 Au NCs 的影响，并提出了可能的反应机制。此外，我们比较了具有三种不同孔结构的 Au NCs 的 SERS 增强效果。以分级多孔 Au NCs 作为 SERS 基底，罗丹明 6G（R6G）的检测限达到 10-10 M。
