Department of Chemistry, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia.
Green Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt.
Molecules. 2023 Mar 3;28(5):2355. doi: 10.3390/molecules28052355.
We reported herein efficient economic high-pressure synthesis procedures for the synthesis of bis(azoles) and bis(azines) by utilizing the bis(enaminone) intermediate. Bis(enaminone) reacted with hydrazine hydrate, hydroxylamine hydrochloride, guanidine hydrochloride, urea, thiourea, and malononitrile to form the desired bis azines and bis azoles. A combination of elemental analyses and spectral data was used to confirm the structures of the products. Compared with conventional heating, the high-pressure Q-Tube method promotes reactions in a short period of time and provides high yields.
我们在此报告了通过利用双（烯胺酮）中间体，高效经济的高压合成双（唑）和双（嗪）的方法。双（烯胺酮）与水合肼、盐酸羟胺、盐酸胍、尿素、硫脲和丙二腈反应，形成所需的双嗪和双唑。通过元素分析和光谱数据的组合来确认产物的结构。与传统加热相比，高压 Q-Tube 方法可在短时间内促进反应，并提供高产率。
