Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, 17671 Athens, Greece.
Department of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, 42100 Trikala, Greece.
Nutrients. 2023 Feb 23;15(5):1112. doi: 10.3390/nu15051112.
The epidemic prevalence of non-alcoholic fatty liver disease (NAFLD), despite extensive research in the field, underlines the importance of focusing on personalized therapeutic approaches. However, nutrigenetic effects on NAFLD are poorly investigated. To this end, we aimed to explore potential gene-dietary pattern interactions in a NAFLD case-control study. The disease was diagnosed with liver ultrasound and blood collection was performed after an overnight fast. Adherence to four a posteriori, data-driven, dietary patterns was used to investigate interactions with PNPLA3-rs738409, TM6SF2-rs58542926, MBOAT7-rs641738, and GCKR-rs738409 in disease and related traits. IBM SPSS Statistics/v21.0 and Plink/v1.07 were used for statistical analyses. The sample consisted of 351 Caucasian individuals. PNPLA3-rs738409 was positively associated with disease odds (OR = 1.575, = 0.012) and GCKR-rs738409 with lnC-reactive protein (CRP) (beta = 0.098, = 0.003) and Fatty Liver Index (FLI) levels (beta = 5.011, = 0.007). The protective effect of a "Prudent" dietary pattern on serum triglyceride (TG) levels in this sample was significantly modified by TM6SF2-rs58542926 ( = 0.007). TM6SF2-rs58542926 carriers may not benefit from a diet rich in unsaturated fatty acids and carbohydrates in regard to TG levels, a commonly elevated feature in NAFLD patients.
非酒精性脂肪性肝病（NAFLD）的流行率尽管在该领域进行了广泛的研究，但仍强调关注个性化治疗方法的重要性。然而，营养遗传学对 NAFLD 的影响研究甚少。为此，我们旨在探讨 NAFLD 病例对照研究中潜在的基因-饮食模式相互作用。通过肝脏超声诊断疾病，并在禁食过夜后采集血液。使用四种后天的、数据驱动的饮食模式来研究与 PNPLA3-rs738409、TM6SF2-rs58542926、MBOAT7-rs641738 和 GCKR-rs738409 之间的相互作用与疾病和相关特征。IBM SPSS Statistics/v21.0 和 Plink/v1.07 用于统计分析。该样本由 351 名白种人个体组成。PNPLA3-rs738409 与疾病几率呈正相关（OR=1.575， =0.012），GCKR-rs738409 与 lnC-反应蛋白（CRP）（beta=0.098， =0.003）和脂肪肝指数（FLI）水平呈正相关（beta=5.011， =0.007）。在该样本中，“谨慎”饮食模式对血清甘油三酯（TG）水平的保护作用显著受 TM6SF2-rs58542926 影响（ =0.007）。TM6SF2-rs58542926 携带者可能不会从富含不饱和脂肪酸和碳水化合物的饮食中获益，因为 TG 水平是 NAFLD 患者常见的升高特征。
