Smyth D D, Blandford D E, Jones D R, Polimeni P I
Department of Pharmacology, University of Manitoba, Winnipeg, Canada.
Can J Physiol Pharmacol. 1987 Sep;65(9):2001-3. doi: 10.1139/y87-313.
Recent studies have demonstrated that an anionic polyacrylamide (Separan, Union Carbide Corp.) decreased the formation of atherosclerotic lesions in the rabbit (Separan AP-30) and increased cardiac output (Separan AP-273) in the rat. Since the effect of these compounds on renal function was unknown, we investigated the dose-response relationship between Separan AP-273 and the renal excretion of electrolytes and water. In the anesthetized rat, intravenous injections of Separan at 0.01, 0.03, 0,10, and 0.30 mg/kg produced a dose-related increase in urine volume, sodium excretion, and osmolar clearance. Potassium excretion was increased less than twofold only at the maximal dose tested. At this high dose, the effect on sodium and water excretion was greater (five- and seven-fold, respectively). Creatinine clearance was not altered by these interventions. As well, the maximal dose studied was previously shown to have no effect on blood flow. These results indicate that Separan AP-273 is a potent diuretic and natriuretic substance. Taken together with similar studies using the poly(ethylene oxide) Polyox WSR N-60K, these results suggest that drag-reducing polymers may represent a novel group of compounds with diuretic and natriuretic effects.
近期研究表明，一种阴离子聚丙烯酰胺（西帕兰，联合碳化物公司）可减少家兔动脉粥样硬化病变的形成（西帕兰AP - 30），并增加大鼠的心输出量（西帕兰AP - 273）。由于这些化合物对肾功能的影响尚不清楚，我们研究了西帕兰AP - 273与电解质及水的肾排泄之间的剂量反应关系。在麻醉大鼠中，静脉注射0.01、0.03、0.10和0.30毫克/千克的西帕兰会使尿量、钠排泄量和渗透清除率呈剂量相关增加。仅在测试的最大剂量下，钾排泄量增加不到两倍。在这个高剂量下，对钠和水排泄的影响更大（分别为五倍和七倍）。这些干预措施未改变肌酐清除率。同样，之前的研究表明所研究的最大剂量对血流没有影响。这些结果表明西帕兰AP - 273是一种强效的利尿和利钠物质。与使用聚环氧乙烷聚奥克斯WSR N - 60K的类似研究结果一起，这些结果表明减阻聚合物可能代表一类具有利尿和利钠作用的新型化合物。
