Bergeron C, Ranalli P J, Miceli P N
Department of Pathology, (Neuropathology), Faculty of Medicine, University of Toronto, Ontario, Canada.
Can J Neurol Sci. 1987 Nov;14(4):564-9.
Thirty cases of Alzheimer's disease and 30 age-matched controls were studied to determine the incidence of cerebral amyloid angiopathy and its relationship to age, neuritic plaque formation, and amyloid plaque content. Cerebral amyloid angiopathy (CAA) was present in 86% of AD cases and 40% of age-matched controls. Its frequent occurrence in AD is not merely a reflection of the advancing age of this group: it was seen only in the presence of neuritic plaques, regardless of age, and represents an integral component of AD. Neuritic plaques however, did occur in the absence of CAA in 17% of all cases. The amount of vascular and plaque amyloid tended to be of comparable severity in many cases, but significant discrepancies were observed, with preferential deposition of amyloid in either plaque or vessel. Our results suggest that neuritic plaque formation and amyloid deposition are linked genetically or etiologically, but independently expressed, without a cause-and-effect relationship.
对30例阿尔茨海默病患者和30名年龄匹配的对照者进行研究，以确定脑淀粉样血管病的发病率及其与年龄、神经炎性斑块形成和淀粉样斑块含量的关系。86%的阿尔茨海默病患者和40%的年龄匹配对照者存在脑淀粉样血管病（CAA）。其在阿尔茨海默病中的频繁出现不仅仅是该组年龄增长的反映：无论年龄大小，仅在存在神经炎性斑块的情况下才会出现，并且是阿尔茨海默病的一个组成部分。然而，在所有病例的17%中，神经炎性斑块在没有CAA的情况下确实出现了。在许多病例中，血管和斑块淀粉样蛋白的量往往具有相当的严重程度，但也观察到了显著差异，淀粉样蛋白在斑块或血管中存在优先沉积。我们的结果表明，神经炎性斑块形成和淀粉样蛋白沉积在遗传或病因上相关，但独立表达，不存在因果关系。
