Glenner G G, Henry J H, Fujihara S
Ann Pathol. 1981;1(2):120-9.
The pathologic manifestations in 45 valid cases of Alzheimer's degeneration were evaluated with specific focus on the presence of Congophilic angiopathy. The latter lesion was found in 89% of the cases and had a definite temporal relationship to the presence of neuritic plaques and neurofibrillary tangles. Two types of plaques were defined, the neuritic and perivascular. The latter was associated spatially with vessels, but not neurofibrillary tangles, while the converse was true of the neuritic plaques. Based on the pattern of mural involvement of vessels, distinctions could be made to differentiate morphologically between cerebral and peripheral amyloid angiopathy. Alzheimer's degeneration appears to be a disease complex with a variety of etiologies. Little or no differences in morphologic characteristics between the presenium and senium process could be discerned. Congophilic angiopathy appears to be a major feature in the pathogenesis of Alzheimer's degeneration.
对45例确诊的阿尔茨海默氏变性病例的病理表现进行了评估，特别关注嗜刚果红血管病的存在情况。在89%的病例中发现了后者病变，并且它与神经炎性斑块和神经原纤维缠结的存在有着明确的时间关系。定义了两种类型的斑块，即神经炎性斑块和血管周围斑块。后者在空间上与血管相关，但与神经原纤维缠结无关，而神经炎性斑块则相反。根据血管壁受累的模式，可以在形态学上区分脑淀粉样血管病和外周淀粉样血管病。阿尔茨海默氏变性似乎是一种病因多样的疾病复合体。在早老期和老年期病程之间，形态学特征几乎没有差异。嗜刚果红血管病似乎是阿尔茨海默氏变性发病机制中的一个主要特征。
