Ali Hiba Hani Mohammed, Al-Akayleh Faisal, Al Jafari Abdel Hadi, Rashid Iyad
Department of Pharmaceutics, College of Pharmacy, University of Sulaimani, Sulaimani P.O. Box 334, Kurdistan Region, Iraq.
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Petra, Amman 11196, Jordan.
Polymers (Basel). 2023 Feb 21;15(5):1063. doi: 10.3390/polym15051063.
The choice of optimum composition of a mixture of binary and ternary excipients for optimum compressional properties was investigated in this work. Excipients were chosen based on three types of excipients: plastic, elastic, and brittle fracture. Mixture compositions were selected based on a one-factor experimental design using the response surface methodology technique. Compressive properties comprising Heckel and Kawakita parameters, work of compression, and tablet hardness were measured as the main responses of this design. The one-factor RSM analysis revealed that there exist specific mass fractions that are associated with optimum responses for binary mixtures. Furthermore, the RSM analysis of the 'mixture' design type for the three components revealed a region of optimal responses around a specific composition. The foregoing had a mass ratio of 80:15:5 for microcrystalline cellulose: starch: magnesium silicate, respectively. Upon comparison using all RSM data, ternary mixtures were found to perform better in compression and tableting properties than binary mixtures. Finally, the finding of an optimal mixture composition has proven effective in its applicability in the context of the dissolution of model drugs (metronidazole and paracetamol).
本研究探讨了二元和三元辅料混合物的最佳组成选择，以获得最佳压缩性能。基于三种类型的辅料选择辅料：塑性、弹性和脆性断裂。混合物组成基于使用响应面法技术的单因素实验设计进行选择。测量包括Heckel和Kawakita参数、压缩功和片剂硬度在内的压缩性能作为该设计的主要响应。单因素响应面法分析表明，二元混合物存在与最佳响应相关的特定质量分数。此外，对三种组分的“混合物”设计类型的响应面法分析揭示了围绕特定组成的最佳响应区域。上述微晶纤维素、淀粉、硅酸镁的质量比分别为80:15:5。使用所有响应面法数据进行比较时，发现三元混合物在压缩和压片性能方面比二元混合物表现更好。最后，发现最佳混合物组成在模型药物（甲硝唑和对乙酰氨基酚）溶解的背景下已证明其适用性有效。
