Tan Hongfei, Zhao Dan, Liu Mingxing, Hong Zongguo, Liu Jingxue, Dai Kang, Xiao Xincai
School of Pharmacy, South-Central Minzu University, Wuhan 430074, China.
National Demonstration Center for Experimental Ethnopharmacology Education, South-Central Minzu University, Wuhan 430074, China.
Polymers (Basel). 2023 Feb 24;15(5):1131. doi: 10.3390/polym15051131.
To avoid risk, spacecraft docking technologies can transport batches of different astronauts or cargoes to a space station. Before now, spacecraft-docking multicarrier/multidrug delivery systems have not been reported on. Herein, inspired by spacecraft docking technology, a novel system including two different docking units, one made of polyamide (PAAM) and on of polyacrylic acid (PAAC), grafted respectively onto polyethersulfone (PES) microcapsules, is designed, based on intermolecular hydrogen bonds in aqueous solution. VB12 and vancomycin hydrochloride were chosen as the release drugs. The release results show that the docking system is perfect, and has a good responsiveness to temperature when the grafting ratio of PES-g-PAAM and PES-g-PAAC is close to 1:1. Below 25 °C, this system exhibited an "off" effect because the polymer chains on the microcapsule's surface produced intermolecular hydrogen bonds. Above 25 °C, when the hydrogen bonds were broken, the microcapsules separated from each other, and the system exhibited an "on" state. The results provide valuable guidance for improving the feasibility of multicarrier/multidrug delivery systems.
为避免风险，航天器对接技术可将多批次不同的宇航员或货物运送到空间站。在此之前，尚未有关于航天器对接多载体/多药物递送系统的报道。在此，受航天器对接技术的启发，基于水溶液中的分子间氢键，设计了一种新型系统，该系统包括两个不同的对接单元，一个由聚酰胺（PAAM）制成，另一个由聚丙烯酸（PAAC）制成，分别接枝到聚醚砜（PES）微胶囊上。选择维生素B12和盐酸万古霉素作为释放药物。释放结果表明，对接系统完美，当PES-g-PAAM和PES-g-PAAC的接枝率接近1:1时，对接系统对温度具有良好的响应性。在25℃以下，该系统表现出“关闭”效应，因为微胶囊表面的聚合物链产生了分子间氢键。在25℃以上，当氢键断裂时，微胶囊相互分离，系统呈现“开启”状态。这些结果为提高多载体/多药物递送系统的可行性提供了有价值的指导。
