Baker H W, Kovacs G T, Burger H G
Medical Research Centre, Prince Henry's Hospital, Melbourne, Australia.
Clin Reprod Fertil. 1987 Feb-Apr;5(1-2):15-25.
A radioimmunoassay employing beta hCG antiserum and tracer and hCG standard was used in an attempt to detect transient luteal phase rises in hCG in urine as evidence of occult pregnancy loss. It was found that the assay lacked specificity and detected 'hCG' surges at midcycle which were not confirmed using a more specific monoclonal antibody based immunoradiometric assay. Measurements on first morning urine samples across midcycle and throughout the luteal phase in 65 cycles from 36 women attempting to conceive revealed no evidence of transient hCG production in the 56 cycles which did not go on to a clinical pregnancy.
采用β-人绒毛膜促性腺激素（β-hCG）抗血清、示踪剂和hCG标准品的放射免疫分析法，试图检测尿液中hCG在黄体期的短暂升高，以此作为隐匿性妊娠丢失的证据。结果发现该检测方法缺乏特异性，在月经周期中期检测到“hCG”激增，但使用更特异的基于单克隆抗体的免疫放射分析法并未得到证实。对36名试图受孕的女性在65个月经周期中，于月经周期中期及整个黄体期采集的晨尿样本进行检测，结果显示，在56个未发展为临床妊娠的周期中，没有证据表明存在hCG的短暂产生。
