Manic-like reaction induced by lorazepam withdrawal.

The benzodiazepine withdrawal symptoms are presented here. The psychotic reactions to benzodiazepine withdrawal are seldom described in the literature. We report a case of acute manic-like reaction induced by sudden lorazepam withdrawal. The sudden release of catecholamines following abrupt cessation of short half-life benzodiazepine is suggested as underlying mechanism for such reaction.