Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Leuk Lymphoma. 2023 Apr;64(4):856-864. doi: 10.1080/10428194.2023.2185086. Epub 2023 Mar 11.
Overexpression of Wilms' tumor () is frequently observed in myelodysplastic syndrome (MDS), which has been proposed as a prognostic marker. However, the prognostic role of expression in different contexts remains to be fully elucidated. We retrospectively assessed the relationships between levels and preexisting prognostic factors to further investigate its prognostic role under different contexts. In our study, expression was positively correlated with WHO 2016 classification and IPSS-R stratification. Lower expression was found in relation to , , or mutations, while mutant patients possessed higher level. Notably, overexpression maintained its inferior prognostic effect on overall survival (OS) in -wild patients but not in -mutated group. In multivariate analysis, higher expression was a risk factors for OS in EB patients without mutations. Overall, expression was useful to predict prognosis for MDS and its prognostic role was impacted by some gene mutations.
Wilms 瘤 1（WT1）在骨髓增生异常综合征（MDS）中常过度表达，已被提议作为一种预后标志物。然而，在不同情况下，表达的预后作用仍有待充分阐明。我们回顾性评估了水平与现有预后因素之间的关系，以进一步研究其在不同情况下的预后作用。在我们的研究中，表达与世界卫生组织 2016 年分类和 IPSS-R 分层呈正相关。较低的表达与、、或突变有关，而突变患者的水平较高。值得注意的是，在 WT1 野生型患者中，过表达对总生存期（OS）仍具有较差的预后作用，但在突变组中则不然。在多变量分析中，在没有 突变的 EB 患者中，较高的表达是 OS 的危险因素。总的来说，WT1 表达有助于预测 MDS 的预后，其预后作用受某些基因突变的影响。
