Chapman R, Fleming T R, Van Damme J, Macdonald J
Henry Ford Hospital, Detroit, MI.
Cancer Treat Rep. 1987 Dec;71(12):1185-7.
Forty patients with locally extensive or metastatic squamous cell carcinoma of the esophagus were registered onto a phase II trial employing cisplatin, vinblastine, and mitoguazone. Of 36 eligible patients, four (11%) had partial responses. None had received prior chemotherapy or radiation therapy. Toxicity was mild to moderate and consisted mostly of nausea and vomiting. The activity of this regimen at the doses and schedule used was minimal. More aggressive use of therapy should be considered for further trials.
40例局部广泛或转移性食管鳞状细胞癌患者登记参加了一项使用顺铂、长春碱和丙脒腙的II期试验。36例符合条件的患者中，4例（11%）有部分缓解。所有患者此前均未接受过化疗或放疗。毒性为轻至中度，主要表现为恶心和呕吐。该方案在所用剂量和疗程下的活性极小。进一步试验应考虑更积极地使用该疗法。
