Kelsen D, Chapman R, Bains M, Heelan R, Dukeman M, Golbey R
Cancer Treat Rep. 1982 Jun;66(6):1427-9.
Twenty-four patients with epidermoid carcinoma of the esophagus have been treated, in a phase II trial, with methyl-GAG using a weekly schedule. Eighteen patients had received prior chemotherapy with cisplatin-containing combinations. Of 23 evaluable patients, four (17%) had partial remissions, each lasting 2 months. All patients had received prior chemotherapy. Toxic effects were manageable and included mild nausea and vomiting, mucositis, and fatigue. Using this schedule, methyl-GAG had modest activity in esophageal cancer, with acceptable toxicity. Its role in combination chemotherapy remains to be defined.
在一项II期试验中，24例食管鳞状细胞癌患者采用每周一次的给药方案接受了甲基甘氨酸二乙胺（methyl-GAG）治疗。18例患者此前接受过含顺铂联合化疗。在23例可评估患者中，4例（17%）获得部分缓解，缓解期均持续2个月。所有患者均接受过前期化疗。毒性反应可控，包括轻度恶心、呕吐、黏膜炎和疲劳。按照此给药方案，甲基甘氨酸二乙胺在食管癌治疗中具有一定活性，毒性可接受。其在联合化疗中的作用尚待确定。
