*Midwest Foot and Ankle Clinics, Hoffman Estates, IL.
J Am Podiatr Med Assoc. 2023 Jan-Feb;113(1). doi: 10.7547/21-071.
Chronic, nonhealing wounds are a growing health-care problem in the United States, affecting more than 6.5 million patients annually and costing the health-care system over $25 billion. Chronic wounds, including diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs), are often difficult to treat, and patients commonly fail to heal even with the most advanced therapies. The present study was designed to evaluate the efficacy and utility of the synthetic hybrid-scale fiber matrix in the treatment of complex chronic nonhealing lower-extremity ulcers refractory to advanced therapies.
A retrospective analysis of 20 patients with a total of 23 wounds (DFUs, n = 18; VLUs, n = 5) who underwent treatment using the synthetic hybrid-scale fiber matrix was conducted. The majority of ulcers (78%) included in this study were refractory to one or multiple previous advanced wound therapies and therefore considered difficult-to-heal ulcers with high failure risk for future therapies.
Subjects had a mean wound age of 16 months and presented with 132 secondary comorbidities and 65 failed interventions and therapies. Treatment of VLUs with the synthetic matrix resulted in complete closure of 100% of the wounds over 244 ± 153 days with an average of 10.8 ± 5.5 applications. Treatment of DFUs with the synthetic matrix resulted in complete closure of 94% of the wounds over 122 ± 69 days with 6.7 ± 3.9 applications.
Treatment with the synthetic hybrid-scale fiber matrix resulted in the closure of 96% of complex chronic ulcers refractory to existing therapies. The inclusion of the synthetic hybrid-scale fiber matrix in wound care programs provides a critical and needed solution for costly, long-standing refractory wounds.
慢性、难愈合的伤口是美国日益严重的医疗保健问题，每年影响超过 650 万名患者，给医疗保健系统造成的损失超过 250 亿美元。慢性伤口，包括糖尿病足溃疡（DFU）和静脉性腿部溃疡（VLU），通常难以治疗，即使采用最先进的治疗方法，患者也常常无法愈合。本研究旨在评估合成混合纤维基质在治疗对先进疗法难治的复杂慢性下肢难愈合溃疡中的疗效和实用性。
对 20 例共 23 处伤口（DFU18 例，VLU5 例）患者使用合成混合纤维基质治疗进行回顾性分析。本研究中纳入的大部分溃疡（78%）对一种或多种先前的先进伤口治疗方法具有难治性，因此被认为是难以愈合的溃疡，未来治疗的失败风险很高。
患者的平均伤口年龄为 16 个月，存在 132 种合并症和 65 次失败的干预和治疗。使用合成基质治疗 VLU，244±153 天内 100%的伤口完全闭合，平均应用 10.8±5.5 次。使用合成基质治疗 DFU，122±69 天内 94%的伤口完全闭合，平均应用 6.7±3.9 次。
使用合成混合纤维基质治疗可使 96%的对现有疗法难治的复杂慢性溃疡闭合。将合成混合纤维基质纳入伤口护理方案为昂贵且长期难治性伤口提供了关键且急需的解决方案。
