胃免疫稳态失衡：胃黏膜疾病发生发展的一个重要因素。

Gastric immune homeostasis imbalance: An important factor in the development of gastric mucosal diseases.

作者信息

Liu Shuhui, Deng Zilin, Zhu Jiaxing, Ma Zhiyuan, Tuo Biguang, Li Taolang, Liu Xuemei

机构信息

Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou Province, China.

Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

出版信息

Biomed Pharmacother. 2023 May;161:114338. doi: 10.1016/j.biopha.2023.114338. Epub 2023 Mar 9.

DOI:10.1016/j.biopha.2023.114338

PMID:36905807

Abstract

The gastric mucosal immune system is a unique immune organ independent of systemic immunity that not only maintains nutrient absorption but also plays a role in resisting the external environment. Gastric mucosal immune disorder leads to a series of gastric mucosal diseases, including autoimmune gastritis (AIG)-related diseases, Helicobacter pylori (H. pylori)-induced diseases, and various types of gastric cancer (GC). Therefore, understanding the role of gastric mucosal immune homeostasis in gastric mucosal protection and the relationship between mucosal immunity and gastric mucosal diseases is very important. This review focuses on the protective effect of gastric mucosal immune homeostasis on the gastric mucosa, as well as multiple gastric mucosal diseases caused by gastric immune disorders. We hope to offer new prospects for the prevention and treatment of gastric mucosal diseases.

摘要

胃黏膜免疫系统是一个独立于全身免疫的独特免疫器官，不仅维持营养物质的吸收，还在抵御外部环境中发挥作用。胃黏膜免疫紊乱会导致一系列胃黏膜疾病，包括自身免疫性胃炎（AIG）相关疾病、幽门螺杆菌（H. pylori）感染所致疾病以及各类胃癌（GC）。因此，了解胃黏膜免疫稳态在胃黏膜保护中的作用以及黏膜免疫与胃黏膜疾病之间的关系非常重要。本综述重点关注胃黏膜免疫稳态对胃黏膜的保护作用，以及胃免疫紊乱引发的多种胃黏膜疾病。我们希望为胃黏膜疾病的防治提供新的前景。