多发性硬化症中的虚弱和复发活动：一项纵向观察。

Frailty and relapse activity in multiple sclerosis: A longitudinal observation.

机构信息

Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy; Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.

出版信息

Mult Scler Relat Disord. 2023 Apr;72:104603. doi: 10.1016/j.msard.2023.104603. Epub 2023 Mar 5.

DOI:10.1016/j.msard.2023.104603

PMID:36905818

Abstract

Recent cross-sectional investigations suggest a relationship between frailty, as measured by Frailty Index (FI), and multiple sclerosis (MS). However, if and how frailty is associated with relapse activity in MS is still unknown. To explore this issue, a one-year follow-up study involving 471 patients was conducted. A univariate regression model showed an inverse association between baseline FI score and the presence of relapse, which was also confirmed in the multivariate model. These results suggest that frailty may reflect pathophysiological mechanisms involved in MS disease activity and that the FI may be used as an enrichment criterion in clinical trials.

摘要

最近的横断面研究表明，衰弱指数（FI）衡量的衰弱与多发性硬化症（MS）之间存在关系。然而，衰弱与 MS 中的复发活动之间的关联以及如何关联仍不清楚。为了探讨这个问题，对 471 名患者进行了为期一年的随访研究。单变量回归模型显示，基线 FI 评分与复发的存在呈负相关，这在多变量模型中也得到了证实。这些结果表明，衰弱可能反映了 MS 疾病活动涉及的病理生理机制，并且 FI 可作为临床试验中的富集标准。