美国 1999-2020 年肥厚型心肌病相关死亡率的人口统计学和趋势。
Demographics and Trends of Hypertrophic Cardiomyopathy-Related Mortality in the United States, 1999-2020.
机构信息
Rochester Regional Health/Unity hospital, Rochester, NY, USA.
Rochester Regional Health/Unity hospital, Rochester, NY, USA.
出版信息
Curr Probl Cardiol. 2023 Jul;48(7):101681. doi: 10.1016/j.cpcardiol.2023.101681. Epub 2023 Mar 10.
There are limited data on the mortality trends of HCM in the United States. To study the demographics and trends of mortality in patients with HCM, a retrospective cohort analysis was done with mortality data of patients with HCM listed as an underlying cause of death in the US Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database (CDC-WONDER) from January 1999 to December 2020. The analysis took place in February 2022. First, we measured HCM-related age-adjusted mortality rate (AAMR) per 100,000 US population stratified by sex, race, ethnicity, and geographic area. We then calculated the Annual Percentage Change (APC) for AAMR for each. A total of 24,655 HCM-related deaths occurred between 1999 and 2020. The AAMR for HCM-related deaths declined from 0.5/100,000 patients in 1999 to 0.2 in 2020. The APC changes are as follows: -6.8 (95% CI: -11.8 to -1.5) from 2002 to 2009, -1.23 (95% CI -13.8 to 13.2) from 2009 to 2014, -6.71 (95% CI -46.2 to 61.7) from 2014 to 2017 and remained at 2.07 (95% CI -26.1 to 41.1) from 2017 to 2020. Men had consistently higher AAMR than women. Overall, AAMR in men was 0.4 (95% CI: 0.4-0.5), and in women was 0.3 (95% CI: 0.3-0.3). A similar trend was noticed in men and women over the years, starting from 1999 (AAMR men: 0.7 and women: 0.4) to 2020 (AAMR men: 0.3 and women: 0.2). AAMRs were highest among black or African American patients 0.6 (95% CI: 0.5-0.6), followed by non-Hispanic and Hispanic white 0.3 (95% CI 0.3-0.3) and Asian or Pacific Islander 0.2 (95% CI 0.2-0.2). There was substantial variation in each region in the US. States such as California, Ohio, Michigan, Oregon, and Wyoming had the highest AAMR. Large metropolitan cities had higher AAMR than non-metropolitan cities. During the study period from 1999 to 2020, HCM-related mortality steadily decreased. The highest AAMR was observed among men, black patients, and residents of metropolitan areas. States such as California, Ohio, Michigan, Oregon, and Wyoming had the highest AAMR.
美国肥厚型心肌病死亡率趋势的数据有限。为了研究肥厚型心肌病患者的人口统计学和死亡率趋势，我们对美国疾病控制与预防中心广域在线流行病学研究数据库（CDC-WONDER）中列出的肥厚型心肌病为根本死因的患者的死亡率数据进行了回顾性队列分析，时间范围为 1999 年 1 月至 2020 年 12 月。分析于 2022 年 2 月进行。首先，我们按性别、种族、族裔和地理位置划分，测量了每 10 万美国人口中与肥厚型心肌病相关的年龄调整死亡率（AAMR）。然后，我们计算了每个 AAMR 的年百分比变化（APC）。1999 年至 2020 年间共发生 24655 例与肥厚型心肌病相关的死亡事件。与肥厚型心肌病相关的死亡 AAMR 从 1999 年的 0.5/100,000 例患者降至 2020 年的 0.2。APC 变化如下：2002 年至 2009 年下降 6.8（95%CI：-11.8 至-1.5），2009 年至 2014 年下降 1.23（95%CI：-13.8 至 13.2），2014 年至 2017 年下降 6.71（95%CI：-46.2 至 61.7），2017 年至 2020 年保持在 2.07（95%CI：-26.1 至 41.1）。男性的 AAMR 始终高于女性。总体而言，男性的 AAMR 为 0.4（95%CI：0.4-0.5），女性为 0.3（95%CI：0.3-0.3）。多年来，男性和女性的趋势相似，从 1999 年（男性 AAMR：0.7，女性 AAMR：0.4）到 2020 年（男性 AAMR：0.3，女性 AAMR：0.2）。黑人或非裔美国人患者的 AAMR 最高，为 0.6（95%CI：0.5-0.6），其次是非西班牙裔和西班牙裔白人，为 0.3（95%CI 0.3-0.3）和亚洲或太平洋岛民，为 0.2（95%CI 0.2-0.2）。美国每个地区的差异都很大。加利福尼亚州、俄亥俄州、密歇根州、俄勒冈州和怀俄明州等州的 AAMR 最高。大都市地区的 AAMR 高于非大都市地区。在 1999 年至 2020 年期间，与肥厚型心肌病相关的死亡率稳步下降。男性、黑人患者和大都市地区居民的 AAMR 最高。加利福尼亚州、俄亥俄州、密歇根州、俄勒冈州和怀俄明州等州的 AAMR 最高。
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