Department of Ophthalmology, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, 665 Shiheongdae-Ro, Seoul, 07442, Korea.
Sci Rep. 2023 Mar 11;13(1):4066. doi: 10.1038/s41598-023-31234-2.
This retrospective study evaluated long-term visual outcomes in children with regressed retinopathy of prematurity (ROP) and correlations between visual acuity (VA) and clinical variables, including fundus findings. We reviewed the medical records of 57 consecutive patients diagnosed with ROP. We analyzed the correlations between best-corrected VA and anatomical fundus findings, such as macular dragging and retinal vascular tortuosity, after ROP regression. The correlations between VA and clinical variables such as gestational age (GA), birth weight (BW), and refractive errors (hyperopia and myopia in spherical equivalent [SE], astigmatism, and anisometropia) were also evaluated. Of 110 eyes, 33.6% had macular dragging; the presence of macular dragging and poor VA were significantly correlated (p = 0.002). Patients with larger macula-to-disc distance/disc diameter ratios had significantly poorer VA (p = 0.036). However, no significant correlation was observed between the VA and vascular tortuosity. Patients with smaller GA and BW had poorer visual outcomes (both, p = 0.007). The larger SE in absolute values, myopia, astigmatism, and anisometropia were significantly associated with poorer visual outcomes as well (all, p < 0.001). In children with regressed ROP, macular dragging, small GA and BW, large SE in absolute values, myopia, astigmatism, and anisometropia may be predictors of poor visual outcomes at early ages.
本回顾性研究评估了退行性早产儿视网膜病变(ROP)患儿的长期视力结果,并分析了视力(VA)与临床变量之间的相关性,包括眼底发现。我们回顾了 57 例连续确诊为 ROP 的患者的病历。我们分析了 ROP 消退后最佳矫正视力(VA)与眼底解剖学发现(如黄斑牵拉和视网膜血管迂曲)之间的相关性。还评估了 VA 与临床变量(如胎龄(GA)、出生体重(BW)和屈光不正(等效球镜中的远视和近视[SE]、散光和屈光参差)之间的相关性。在 110 只眼中,33.6%存在黄斑牵拉;黄斑牵拉和低视力与存在显著相关性(p=0.002)。黄斑与视盘直径比较大的患者视力明显较差(p=0.036)。然而,VA 与血管迂曲之间无显著相关性。GA 和 BW 较小的患者视力结果较差(均为 p=0.007)。绝对值较大的 SE、近视、散光和屈光参差也与较差的视力结果显著相关(均为 p<0.001)。在退行性 ROP 患儿中,黄斑牵拉、GA 和 BW 较小、绝对值较大的 SE、近视、散光和屈光参差可能是早期视力不良的预测因素。