Suarez Luz M, Diaz-Del Cerro Estefania, Felix Judith, Gonzalez-Sanchez Monica, Ceprian Noemi, Guerra-Perez Natalia, Novelle Marta G, Martinez de Toda Irene, De la Fuente Monica
Department of Genetics, Physiology, and Microbiology (Unit of Animal Physiology), Faculty of Biology, Complutense University, Madrid, Spain.
Department of Genetics, Physiology, and Microbiology (Unit of Animal Physiology), Faculty of Biology, Complutense University, Madrid, Spain; Institute of Investigation Hospital 12 Octubre (imas12), Madrid, Spain.
Mech Ageing Dev. 2023 Apr;211:111798. doi: 10.1016/j.mad.2023.111798. Epub 2023 Mar 11.
Endocrine, nervous, and immune systems work coordinately to maintain the global homeostasis of the organism. They show sex differences in their functions that, in turn, contribute to sex differences beyond reproductive function. Females display a better control of the energetic metabolism and improved neuroprotection and have more antioxidant defenses and a better inflammatory status than males, which is associated with a more robust immune response than that of males. These differences are present from the early stages of life, being more relevant in adulthood and influencing the aging trajectory in each sex and may contribute to the different life lifespan between sexes.
内分泌系统、神经系统和免疫系统协同工作，以维持机体的整体稳态。它们在功能上存在性别差异，进而导致了生殖功能以外的性别差异。与男性相比，女性对能量代谢的控制更好，神经保护作用更强，具有更多的抗氧化防御机制和更好的炎症状态，这与比男性更强健的免疫反应相关。这些差异在生命早期就已存在，在成年期更为明显，并影响着两性的衰老轨迹，可能导致两性不同的寿命。
