Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Environ Res. 2023 Jun 1;226:115670. doi: 10.1016/j.envres.2023.115670. Epub 2023 Mar 11.
This study aimed to investigate the composite effects of different kinds of phthalates on depression risk in the U.S population.
11731 participants were included from the National Health and Nutrition Examination Survey (NHANES), a national cross-sectional survey. Twelve urinary phthalate metabolites were used to evaluate the level of phthalates exposure. Phthalates levels were devided into four quartiles. High phthalate was defined as having values in the highest quartile.
Urinary mono-isobutyl phthalate (MiBP) and mono-benzyl phthalate (MBzP) were estimated as the independent risk factors for depression by mutivariate logistic regression analyses. Compared with the lowest quartile group of MiBP or MBzP, an incrementally higher risk of depression and moderate/severe depression was observed in the highest quartile (all P <0.05). It was observed that incrementally higher risk of depression and moderate/severe depression were associated with more numbers of high phthalates parameter (P <0.001 and P = 0.003, respectively). A significant interaction between race (Non-Hispanic Black vs. Mexican American) and 2 parameters (having value in the highest quartile of both MiBP and MBzP) was detected for depression (P = 0.023) and moderate/severe depression (P = 0.029).
Individuals with more numbers of high phthalates parameter were at higher risk of depression and moderate/severe depression. Non-Hispanic Black participants were more likely to be affected by high levels of MiBP and MBzP exposure than Mexican American participants.
本研究旨在探讨美国人群中不同种类邻苯二甲酸酯对抑郁风险的综合影响。
本研究纳入了来自全国健康和营养调查（NHANES）的 11731 名参与者，该调查是一项全国性的横断面研究。使用 12 种尿邻苯二甲酸酯代谢物来评估邻苯二甲酸酯暴露水平。将邻苯二甲酸酯水平分为四个四分位区间。高邻苯二甲酸酯定义为处于最高四分位区间的值。
多变量逻辑回归分析显示，尿单异丁基邻苯二甲酸酯（MiBP）和单苄基邻苯二甲酸酯（MBzP）被估计为抑郁的独立危险因素。与 MiBP 或 MBzP 的最低四分位组相比，MiBP 或 MBzP 最高四分位组的抑郁和中重度抑郁风险呈递增趋势（均 P <0.05）。观察到随着高邻苯二甲酸酯参数数量的增加，抑郁和中重度抑郁的风险呈递增趋势（均 P <0.001 和 P=0.003）。种族（非西班牙裔黑人与墨西哥裔美国人）和 2 个参数（MiBP 和 MBzP 的最高四分位值）之间存在显著的交互作用，与抑郁（P=0.023）和中重度抑郁（P=0.029）相关。
具有更多高邻苯二甲酸酯参数的个体患抑郁和中重度抑郁的风险更高。与墨西哥裔美国人参与者相比，非西班牙裔黑人参与者更容易受到 MiBP 和 MBzP 高水平暴露的影响。
