Liu Yun-An, Hsu Heng-Jung, Pan Heng-Chih, Sun Chiao-Yin, Chen Yih-Ting, Lee Chin-Chan, Su Feng-Chieh, Wei Yi-Chia, Hsu Cheng-Kai, Chen Chun-Yu
Department of Nephrology, Chang Gung Memorial Hospital, Keelung Branch 222, Mai-Chin Road, Keelung 20401, Taiwan, Republic of China.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Curr Res Toxicol. 2025 Feb 25;8:100225. doi: 10.1016/j.crtox.2025.100225. eCollection 2025.
The rising prevalence of depressive disorders has sparked concerns regarding environmental risk factors, particularly exposure to endocrine-disrupting chemicals (EDCs). However, the link between EDC exposure and depressive symptoms remains largely unexplored.
The Chang Gung Community Medicine Research Center carried out a cross-sectional study across four regions in northeastern Taiwan. Out of 887 participants, 120 subjects were chosen according to their EDC exposure scores. These participants underwent urinary EDC analysis and were evaluated for depressive symptoms through the standardized Hospital Anxiety and Depression Scale - Depression subscale (HADS-D) questionnaire.
Participants with HADS-D scores ≥ 8 exhibited significantly higher EDC exposure score compared to those with lower scores. The correlation analyses identified a notible positive association between urinary monobenzyl phthalate (MBzP) levels and HADS-D scores ( = 0.244, = 0.007). Multiple regression analysis revealed that MBzP was independently linked to increased HADS-D scores in a positive manner (β ± SE: 0.139 ± 0.050, = 0.006). Multivariable logistic regression indicated that higher MBzP (OR: 1.150, 95 % CI: 1.036-1.278, = 0.009) and methylparaben (MP) levels (OR: 1.008, 95 % CI: 1.003-1.013, p < 0.001) showed a significant correlation with the likelihood of HADS-D scores ≥ 8. Receiver operating characteristic curve analysis demonstrated that elevated levels of MBzP, MP and the EDCs exposure score were associated with a greater likelihood of depressive symptoms.
Exposure to EDCs, particularly MBzP and MP, could be associated with a heightened risk of depressive symptoms.
抑郁症患病率的上升引发了人们对环境风险因素的关注，尤其是接触内分泌干扰化学物质（EDC）。然而，EDC暴露与抑郁症状之间的联系在很大程度上仍未得到探索。
长庚社区医学研究中心在台湾东北部的四个地区进行了一项横断面研究。在887名参与者中，根据他们的EDC暴露分数选择了120名受试者。这些参与者接受了尿液EDC分析，并通过标准化的医院焦虑抑郁量表-抑郁分量表（HADS-D）问卷对抑郁症状进行了评估。
与得分较低的参与者相比，HADS-D得分≥8的参与者表现出明显更高的EDC暴露分数。相关性分析确定尿中邻苯二甲酸单苄酯（MBzP）水平与HADS-D得分之间存在显著正相关（r = 0.244，p = 0.007）。多元回归分析显示，MBzP以正向方式独立关联HADS-D得分升高（β±SE：0.139±0.050，p = 0.006）。多变量逻辑回归表明，较高的MBzP（OR：1.150，95%CI：1.036 - 1.278，p = 0.009）和对羟基苯甲酸甲酯（MP）水平（OR：1.008，95%CI：1.003 - 1.013，p < 0.001）与HADS-D得分≥8的可能性显著相关。受试者工作特征曲线分析表明，MBzP、MP水平升高以及EDC暴露分数与抑郁症状的可能性更大相关。
接触EDC，尤其是MBzP和MP，可能与抑郁症状风险增加有关。
