从酸榄仁根皮中分离得到的化合物在多发性骨髓瘤细胞系中的抗增殖活性。

Antiproliferative activity of compounds isolated from the root bark of Lannea acida in multiple myeloma cell lines.

作者信息

Saraux Noémie, Bruna Laure, Ebrahimi Samad N, Karimou Soumana, Christen Philippe, Cuendet Muriel

机构信息

School of Pharmaceutical Sciences, University of Geneva, Rue Michel-Servet 1, 1211, Geneva 4, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1211, Geneva 4, Switzerland.

Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, 1983963113, Tehran, Iran.

出版信息

Phytochemistry. 2023 May;209:113641. doi: 10.1016/j.phytochem.2023.113641. Epub 2023 Mar 10.

DOI:10.1016/j.phytochem.2023.113641

PMID:36907430

Abstract

Lannea acida A. Rich. is a native plant of West Africa used in traditional medicine against diarrhea, dysentery, rheumatism, and women infertility. Eleven compounds were isolated from the dichloromethane root bark extract using various chromatographic techniques. Among those, nine compounds have not been previously reported, i.e. one cardanol derivative, two alkenyl 5-hydroxycyclohex-2-en-1-ones, three alkenyl cyclohex-4-ene-1,3-diols, two alkenyl 7-oxabicyclo[4.1.0]hept-4-en-3-ols, and one alkenyl 4,5-dihydroxycyclohex-2-en-1-one, together with two known cardanols. The structure of the compounds was elucidated using NMR, HRESIMS, ECD, IR, and UV. Their antiproliferative activity was evaluated in three multiple myeloma cell lines: RPMI 8226, MM.1S, and MM.1R. Two compounds showed activity in all cell lines with IC values < 5 μM. Further investigations are needed to understand the mechanism of action.

摘要

酸榄仁（Lannea acida A. Rich.）是一种原产于西非的植物，在传统医学中用于治疗腹泻、痢疾、风湿和女性不孕症。采用多种色谱技术从二氯甲烷根皮提取物中分离出11种化合物。其中，9种化合物此前未见报道，即1种腰果酚衍生物、2种烯基5-羟基环己-2-烯-1-酮、3种烯基环己-4-烯-1,3-二醇、2种烯基7-氧杂双环[4.1.0]庚-4-烯-3-醇和1种烯基4,5-二羟基环己-2-烯-1-酮，以及2种已知的腰果酚。通过核磁共振（NMR）、高分辨电喷雾电离质谱（HRESIMS）、电子圆二色谱（ECD）、红外光谱（IR）和紫外光谱（UV）对化合物的结构进行了阐明。在三种多发性骨髓瘤细胞系RPMI 8226、MM.1S和MM.1R中评估了它们的抗增殖活性。两种化合物在所有细胞系中均表现出活性，IC值<5μM。需要进一步研究以了解其作用机制。