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从 39 孕周开始进行胎儿监测,以降低南亚裔出生女性的死胎发生率。

Fetal surveillance from 39 weeks' gestation to reduce stillbirth in South Asian-born women.

机构信息

Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia.

Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia.

出版信息

Am J Obstet Gynecol. 2023 Sep;229(3):286.e1-286.e9. doi: 10.1016/j.ajog.2023.02.028. Epub 2023 Mar 11.

Abstract

BACKGROUND

In July 2017, the State of Victoria's largest maternity service implemented a new clinical guideline to reduce the rates of stillbirth at term for South Asian women.

OBJECTIVE

This study aimed to evaluate the impact of offering fetal surveillance from 39 weeks to South Asian-born women on rates of stillbirth and neonatal and obstetrical interventions.

STUDY DESIGN

This was a cohort study of all women receiving antenatal care at 3 large metropolitan university-affiliated teaching hospitals in Victoria, who gave birth in the term period between January 2016 and December 2020. Differences in rates of stillbirth, neonatal deaths, perinatal morbidities, and interventions after July 2017 were determined. Multigroup interrupted time-series analysis was used to assess changes in rates of stillbirth and induction of labor.

RESULTS

A total of 3506 South Asian-born women gave birth before, and 8532 after the change in practice. There was a 64% reduction in term stillbirth (95% confidence interval, 87% to 2%; P=.047) after the change in practice from 2.3 per 1000 births to 0.8 per 1000 births. The rates of early neonatal death (3.1/1000 vs 1.3/1000; P=.03) and special care nursery admission (16.5% vs 11.1%; P<.001) also decreased. There were no significant differences in admission to the neonatal intensive care unit, 5-minute Apgar score <7, or birthweight, or differences in the trends of induction of labor per month.

CONCLUSION

Fetal monitoring from 39 weeks may offer an alternative to routine earlier induction of labor to reduce the rates of stillbirth without causing an increase in neonatal morbidity and attenuating trends in obstetrical interventions.

摘要

背景

2017 年 7 月,维多利亚州最大的产科服务机构实施了一项新的临床指南,旨在降低南亚裔女性足月产时的死胎率。

目的

本研究旨在评估为南亚裔女性提供 39 周后胎儿监测对死胎率以及新生儿和产科干预的影响。

研究设计

这是一项队列研究,纳入了在维多利亚州 3 家大型都市大学附属医院接受产前护理并于 2016 年 1 月至 2020 年 12 月期间足月分娩的所有女性。比较了 2017 年 7 月前后死胎率、新生儿死亡、围产儿发病率和干预措施的差异。采用多组中断时间序列分析评估死胎率和引产的变化。

结果

共有 3506 名南亚裔出生的女性在实践改变前分娩,8532 名女性在实践改变后分娩。实践改变后,足月产死胎率从 2.3/1000 降至 0.8/1000,降幅为 64%(95%置信区间,87%至 2%;P=.047)。早期新生儿死亡(3.1/1000 比 1.3/1000;P=.03)和新生儿重症监护病房收治率(16.5%比 11.1%;P<.001)也有所下降。新生儿重症监护病房收治率、5 分钟 Apgar 评分<7 和出生体重无显著差异,引产趋势也无差异。

结论

39 周后进行胎儿监测可能是替代常规提前引产的一种方法,在不增加新生儿发病率的情况下降低死胎率,并减弱产科干预的趋势。

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