β 地中海贫血的发病机制 II：铁过载。
Pathogenic Mechanisms in Thalassemia II: Iron Overload.
机构信息
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1690, USA.
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1690, USA.
出版信息
Hematol Oncol Clin North Am. 2023 Apr;37(2):353-363. doi: 10.1016/j.hoc.2022.12.006.
PMID:36907608
Abstract
Iron overload remains a lethal complication of β-thalassemia and other anemias caused by ineffective erythropoiesis. This review discusses the pathogenetic mechanisms of iron overload in thalassemia, at organismal, cellular, and molecular levels.
摘要
铁过载仍然是β-地中海贫血和其他无效红细胞生成引起的贫血的致命并发症。本文综述了地中海贫血中铁过载的发病机制，包括机体、细胞和分子水平。
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