Ali K H, Feeley T W, Bieber M, McGrath B, Teng N N
Department of Anesthesia, Stanford University School of Medicine, California 94305.
Circ Shock. 1987;23(4):285-93.
The in vivo cardiovascular effect of intravenous administration of monophosphoryl lipid A (mp-lipid A) and diphosphoryl lipid A (dp-lipid A) in awake New Zealand white rabbits was investigated. Observed changes were evaluated in comparison to a control group and an endotoxin-treated group. Rabbits given lipid A showed a significant depression in cardiac index (p less than .025), mean arterial pressure (p less than .025, dp-lipid A only), arterial carbon dioxide tension (p less than .025), and total leukocyte count (p less than .05) compared to controls. Animals receiving lipid A tended to respond overall in a manner closely matching that of the endotoxin group. Dosages of lipid A given were approximately 3.5 times larger than the endotoxin dosages with respect to actual number of molecules administered (1.25-2.0 times larger by mass). These results indicate that lipid A is active in producing the cardiovascular and leukopenic effects characteristic of experimental septic shock.
研究了静脉注射单磷酰脂质A（mp-脂质A）和双磷酰脂质A（dp-脂质A）对清醒新西兰白兔的体内心血管效应。将观察到的变化与对照组和内毒素处理组进行比较评估。与对照组相比，给予脂质A的兔子心脏指数显著降低（p < 0.025）、平均动脉压降低（仅dp-脂质A，p < 0.025）、动脉二氧化碳分压降低（p < 0.025）以及白细胞总数降低（p < 0.05）。接受脂质A的动物总体反应倾向于与内毒素组密切匹配。就实际给药的分子数量而言，给予的脂质A剂量约为内毒素剂量的3.5倍（按质量计算大1.25 - 2.0倍）。这些结果表明，脂质A在产生实验性脓毒性休克特有的心血管和白细胞减少效应方面具有活性。
