Zhengzhou Key Laboratory of Children's Infection and Immunity, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, P.R. China.
The Center of Henan Children's Neurodevelopmental Engineering Research, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, P.R. China.
Ann Med. 2023 Dec;55(1):920-925. doi: 10.1080/07853890.2023.2185673.
It is possible that neonates with pneumonia also have unrecognized sepsis. Identifying sepsis in neonates with pneumonia may cause some trouble for clinicians. This study aimed to evaluate the clinical value of the procalcitonin-to-albumin ratio (PAR) in identifying sepsis in neonates with pneumonia.
We retrospectively included 912 neonates with pneumonia from January 2016 to July 2021. Clinical and laboratory data were collected from electronic medical records. Among neonates with pneumonia, 561 neonates were diagnosed with sepsis, according to the International Pediatric Sepsis Consensus. Neonates were divided into a sepsis group and a pneumonia group. A multivariate logistic regression analysis was used to evaluate whether PAR was a potential independent indicator for identifying sepsis in neonates with pneumonia. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic value of PAR in sepsis.
Neonates with sepsis have a higher PAR ( < 0.001). Correlation analysis showed that PAR was positively correlated with the level of C-reactive protein ( = 0.446, < 0.001). Multiple logistic regression analysis showed that PAR was an independent predictor of the presence of sepsis in neonates with pneumonia. ROC curve analysis revealed that PAR had good power in identifying sepsis in neonates with pneumonia (area under curve (AUC) = 0.72, 95% confidence interval (CI), 0.68-0.75, < 0.001).
PAR can be used as a new biomarker to identify sepsis in neonates with pneumonia.
患有肺炎的新生儿也可能存在未被识别的败血症。在患有肺炎的新生儿中识别败血症可能会给临床医生带来一些麻烦。本研究旨在评估降钙素原与白蛋白比值（PAR）在识别患有肺炎的新生儿败血症中的临床价值。
我们回顾性纳入了 2016 年 1 月至 2021 年 7 月期间 912 例患有肺炎的新生儿。从电子病历中收集了临床和实验室数据。在患有肺炎的新生儿中，根据国际儿科败血症共识，有 561 例新生儿被诊断为败血症。将新生儿分为败血症组和肺炎组。采用多变量逻辑回归分析评估 PAR 是否是识别患有肺炎的新生儿败血症的潜在独立指标。进行受试者工作特征（ROC）曲线分析以评估 PAR 在败血症中的诊断价值。
患有败血症的新生儿的 PAR 更高（ < 0.001）。相关性分析表明，PAR 与 C 反应蛋白水平呈正相关（ = 0.446， < 0.001）。多变量逻辑回归分析表明，PAR 是肺炎新生儿败血症存在的独立预测因子。ROC 曲线分析表明，PAR 在识别肺炎新生儿败血症方面具有良好的效能（曲线下面积（AUC）= 0.72，95%置信区间（CI），0.68-0.75， < 0.001）。
PAR 可作为一种新的生物标志物，用于识别患有肺炎的新生儿败血症。
