Jeong Keun-Yeong
Research and Development Center, PearlsinMires, Seoul 03690, South Korea.
World J Gastrointest Oncol. 2023 Feb 15;15(2):215-224. doi: 10.4251/wjgo.v15.i2.215.
With the establishment of the immune surveillance mechanism since the 1950s, attempts have been made to activate the immune system for cancer treatment through the discovery of various cytokines or the development of antibodies up to now. The fruits of these efforts have contributed to the recognition of the 3 generation of anticancer immunotherapy as the mainstream of cancer treatment. However, the limitations of cancer immunotherapy are also being recognized through the conceptual establishment of cold tumors recently, and colorectal cancer (CRC) has become a major issue from this therapeutic point of view. Here, it is emphasized that non-clinical strategies to overcome the immunosuppressive environment and clinical trials based on these basic investigations are being made on the journey to achieve better treatment outcomes for the treatment of cold CRC.
自20世纪50年代免疫监视机制建立以来，人们一直尝试通过发现各种细胞因子或开发抗体来激活免疫系统以治疗癌症。这些努力的成果促使三代抗癌免疫疗法成为癌症治疗的主流。然而，随着近年来冷肿瘤概念的确立，癌症免疫疗法的局限性也逐渐被认识到，从这个治疗角度来看，结直肠癌（CRC）已成为一个主要问题。在此强调，为实现冷型CRC更好的治疗效果，目前正在探索克服免疫抑制环境的非临床策略，并基于这些基础研究开展临床试验。
