Rando Emanuele, Matteini Elena, Guerriero Silvia, Fantoni Massimo
Dipartimento di Sicurezza e Bioetica - Sezione di Malattie Infettive, Università Cattolica del Sacro Cuore, Rome, Italy.
Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Infez Med. 2023 Mar 1;31(1):31-35. doi: 10.53854/liim-3101-5. eCollection 2022.
Gram-negative infections (GNIs) are frequently encountered both in community and hospital settings. Frail patients, defined as elderly individuals with multiple comorbidities, are particularly vulnerable to them. The presentation and the course of GNIs differ in aged patients compared with younger ones, making their management a unique challenge. This review aimed to outline the essential elements of the presentation, diagnosis, and outcome of GNIs in frail individuals.
MEDLINE/PubMed library search was performed using the following terms: frail, frailty, elderly, Gram-negative, infections, pneumonia, urinary tract infection, and bloodstream infection for the purpose of the review.
Elderly patients with multimorbidity represent a distinct population with relevant differences in GNIs presentation, diagnosis, and outcome. Several pitfalls should be avoided and appropriately addressed when facing GNIs in this group of patients. Future studies focusing on this population should be encouraged.
革兰氏阴性菌感染（GNIs）在社区和医院环境中都很常见。体弱患者，即患有多种合并症的老年人，尤其容易受到感染。与年轻患者相比，老年患者的GNIs表现和病程有所不同，这使得对其进行管理成为一项独特的挑战。本综述旨在概述体弱个体中GNIs的表现、诊断和预后的基本要素。
为进行本综述，使用以下术语在MEDLINE/PubMed图书馆进行检索：体弱、虚弱、老年人、革兰氏阴性菌、感染、肺炎、尿路感染和血流感染。
患有多种合并症的老年患者是一个独特的群体，在GNIs的表现、诊断和预后方面存在相关差异。在面对这组患者的GNIs时，应避免并妥善处理几个陷阱。应鼓励针对该人群的未来研究。
