急性心肌梗死后“无复流”现象的机制：周细胞的潜在作用

Mechanisms of the "No-Reflow" Phenomenon After Acute Myocardial Infarction: Potential Role of Pericytes.

作者信息

Kaul Sanjiv, Methner Carmen, Cao Zhiping, Mishra Anusha

机构信息

Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.

Jungers Center for Neurosciences Research, Department of Neurology, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.

出版信息

JACC Basic Transl Sci. 2022 Sep 21;8(2):204-220. doi: 10.1016/j.jacbts.2022.06.008. eCollection 2023 Feb.

Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at altering pericyte function in myocardial ischemia and infarction.