Pearce L, Galán-Arriola C, Bell R M, Carr R D, Cunningham J, Davidson S M, Ghosh A K, Giesz S, Golforoush P, Gourine A V, Hermann D M, Heusch G, Ibanez B, Kalkhoran S Beikoghli, Lecour S, Lukhna K, Ntsekhe M, Sack M N, Unwin R J, Vilahur G, Walker J M, Yellon D M
The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, London, WC1E 6HX, UK.
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Basic Res Cardiol. 2025 Apr;120(2):287-299. doi: 10.1007/s00395-024-01094-6. Epub 2024 Dec 16.
A long-standing aim in the setting of various pathologies including acute myocardial infarction, chronic kidney disease (CKD), and ischaemic stroke, has been to identify successful approaches to augment cellular and organ protection. Although the continual evolution and refinement of ideas over the past few decades has allowed the field to progress, we are yet to realise successful clinical translation of this concept. The 12th Hatter Cardiovascular Workshop identified a number of important points and key questions for future research relating to cardio- and neuro-protection and interorgan communication. Specific topics that were discussed include the 'cardio-metabolic-renal' axis of organ protection, the parasympathetic signalling hypothesis, the role of the coronary microvasculature in myocardial infarction, the RISK pathway of cardioprotection, extracellular vesicles and the way forward, the future for clinical studies of remote ischaemic conditioning, and new experimental models for cardio-oncology investigations.
在包括急性心肌梗死、慢性肾脏病（CKD）和缺血性中风在内的各种病理情况下，一个长期目标一直是确定增强细胞和器官保护的成功方法。尽管在过去几十年中，相关理念不断演变和完善，推动了该领域的发展，但我们尚未实现这一概念在临床上的成功转化。第12届哈特心血管研讨会确定了一些与心脏和神经保护以及器官间通讯相关的未来研究的重要要点和关键问题。讨论的具体主题包括器官保护的“心脏-代谢-肾脏”轴、副交感神经信号假说、冠状动脉微血管在心肌梗死中的作用、心脏保护的RISK途径、细胞外囊泡及其未来发展方向、远程缺血预处理临床研究的未来，以及心脏肿瘤学研究的新实验模型。
