轻度认知障碍个体中，浅表神经丛的黄斑血管密度与阿尔茨海默病的脑脊液核心生物标志物无关：NORFACE队列研究。
Macular vessel density in the superficial plexus is not associated to cerebrospinal fluid core biomarkers for Alzheimer's disease in individuals with mild cognitive impairment: The NORFACE cohort.
作者信息
Marquié Marta, García-Sánchez Ainhoa, Alarcón-Martín Emilio, Martínez Joan, Castilla-Martí Miguel, Castilla-Martí Luis, Orellana Adelina, Montrreal Laura, de Rojas Itziar, García-González Pablo, Puerta Raquel, Olivé Clàudia, Cano Amanda, Hernández Isabel, Rosende-Roca Maitée, Vargas Liliana, Tartari Juan Pablo, Esteban-De Antonio Ester, Bojaryn Urszula, Ricciardi Mario, Ariton Diana M, Pytel Vanesa, Alegret Montserrat, Ortega Gemma, Espinosa Ana, Pérez-Cordón Alba, Sanabria Ángela, Muñoz Nathalia, Lleonart Núria, Aguilera Núria, Tárraga Lluís, Valero Sergi, Ruiz Agustín, Boada Mercè
机构信息
Ace Alzheimer Center Barcelona, Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Networking Research Center on Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
出版信息
Front Neurosci. 2023 Feb 23;17:1076177. doi: 10.3389/fnins.2023.1076177. eCollection 2023.
BACKGROUND
Optical coherence tomography angiography (OCT-A) is a novel method in the dementia field that allows the detection of retinal vascular changes. The comparison of OCT-A measures with established Alzheimer's disease (AD)-related biomarkers is essential to validate the former as a marker of cerebrovascular impairment in the AD continuum. We aimed to investigate the association of macular vessel density (VD) in the superficial plexus quantified by OCT-A with the AT(N) classification based on cerebrospinal fluid (CSF) Aβ1-42, p181-tau and t-tau measurements in individuals with mild cognitive impairment (MCI).
MATERIALS AND METHODS
Clinical, demographic, ophthalmological, OCT-A and CSF core biomarkers for AD data from the Neuro-ophthalmology Research at Fundació ACE (NORFACE) project were analyzed. Differences in macular VD in four quadrants (superior, nasal, inferior, and temporal) among three AT(N) groups [Normal, Alzheimer and Suspected non-Alzheimer pathology (SNAP)] were assessed in a multivariate regression model, adjusted for age, ε4 status, hypertension, diabetes mellitus, dyslipidemia, heart disease, chronic obstructive pulmonary disease and smoking habit, using the Normal AT(N) group as the reference category.
RESULTS
The study cohort comprised 144 MCI participants: 66 Normal AT(N), 45 Alzheimer AT(N) and 33 SNAP AT(N). Regression analysis showed no significant association of the AT(N) groups with any of the regional macular VD measures (all, > 0.16). The interaction between sex and AT(N) groups had no effect on differentiating VD. Lastly, CSF Aβ1-42, p181-tau and t-tau measures were not correlated to VD (all < 0.13; > 0.13).
DISCUSSION
Our study showed that macular VD measures were not associated with the AT(N) classification based on CSF biomarkers in patients with MCI, and did not differ between AD and other underlying causes of cognitive decline in our cohort.
背景
光学相干断层扫描血管造影（OCT-A）是痴呆领域的一种新方法，可检测视网膜血管变化。将OCT-A测量结果与已确立的阿尔茨海默病（AD）相关生物标志物进行比较，对于验证前者作为AD连续体中脑血管损伤标志物至关重要。我们旨在研究通过OCT-A量化的浅表丛中黄斑血管密度（VD）与基于脑脊液（CSF）Aβ1-42、p181- tau和总tau测量的AT(N)分类在轻度认知障碍（MCI）个体中的相关性。
材料和方法
分析了来自Fundació ACE神经眼科研究（NORFACE）项目的AD数据的临床、人口统计学、眼科、OCT-A和CSF核心生物标志物。在多变量回归模型中评估了三个AT(N)组[正常、阿尔茨海默病和疑似非阿尔茨海默病病理（SNAP）]之间四个象限（上、鼻、下和颞）黄斑VD的差异，并对年龄、ε4状态、高血压、糖尿病、血脂异常、心脏病、慢性阻塞性肺疾病和吸烟习惯进行了调整，以正常AT(N)组作为参考类别。
结果
研究队列包括144名MCI参与者：66名正常AT(N)、45名阿尔茨海默病AT(N)和33名SNAP AT(N)。回归分析显示，AT(N)组与任何区域黄斑VD测量值均无显著相关性（所有P>0.16）。性别与AT(N)组之间的相互作用对区分VD没有影响。最后，CSF Aβ1-42、p181- tau和总tau测量值与VD均无相关性（所有P<0.13；P>0.13）。
讨论
我们的研究表明，MCI患者的黄斑VD测量值与基于CSF生物标志物的AT(N)分类无关，并且在我们的队列中，AD与其他认知下降潜在原因之间没有差异。
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