Su Binbin, Zhu Xiaoxuan, Yang Kai, Xiao Yunfan, Li Chunmei, Shi Keai, Qu Jia, Lu Fan, Li Ming, Cui Lele
Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, 325003, People's Republic of China.
Eye Vis (Lond). 2022 Oct 1;9(1):38. doi: 10.1186/s40662-022-00307-0.
To assess age- and sex-related changes in the superficial retinal capillary plexus (SCP) and deep retinal capillary plexus (DCP) in healthy Chinese adults.
In this cross-sectional study, all data were derived from the community-based Jidong Eye Cohort Study. Participants underwent optical coherence tomography angiography (OCTA) and other ocular and systemic examinations. The vessel densities of the whole measured area, parafovea, and four quadrants in the SCP and DCP were measured.
We recruited 1036 eyes of 1036 healthy participants; the mean age was 40.4 ± 9.8 years, and 449 (43.3%) participants were males. The SCP and DCP vessel densities in all regions, except for temporal and nasal regions in the SCP, non-linearly decreased with age. The DCP vessel densities began to decrease at approximately 35 years of age, while the SCP vessel densities began to decrease at approximately 40 years of age. The DCP vessel densities decreased more rapidly than the SCP vessel densities at 35-50 years of age. The DCP vessel densities remained stable or slightly decreased after the age of 50 years in females, while those decreased linearly in most regions in males.
The retinal vessel density decreased earlier and more rapidly in the DCP than in the SCP, and the effect of aging on the DCP vessel density was sex-dependent. Our findings suggest that age and sex should be considered when interpreting clinical quantitative OCTA data.
评估健康中国成年人视网膜浅表毛细血管丛（SCP）和视网膜深层毛细血管丛（DCP）与年龄和性别的相关变化。
在这项横断面研究中，所有数据均来自基于社区的冀东眼病队列研究。参与者接受了光学相干断层扫描血管造影（OCTA）以及其他眼部和全身检查。测量了SCP和DCP中整个测量区域、黄斑旁以及四个象限的血管密度。
我们招募了1036名健康参与者的1036只眼睛；平均年龄为40.4±9.8岁，449名（43.3%）参与者为男性。除SCP的颞侧和鼻侧区域外，所有区域的SCP和DCP血管密度均随年龄呈非线性下降。DCP血管密度在大约35岁时开始下降，而SCP血管密度在大约40岁时开始下降。在35至50岁时，DCP血管密度下降速度比SCP血管密度更快。50岁以后，女性的DCP血管密度保持稳定或略有下降，而男性大多数区域的DCP血管密度呈线性下降。
DCP中视网膜血管密度比SCP下降更早且更快，并且衰老对DCP血管密度的影响存在性别差异。我们的研究结果表明，在解释临床定量OCTA数据时应考虑年龄和性别因素。
