Srisaikaew Patcharaporn, Chad Jordan A, Mahakkanukrauh Pasuk, Anderson Nicole D, Chen J Jean
Ph.D. Program in Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Front Neurosci. 2023 Feb 22;17:1049609. doi: 10.3389/fnins.2023.1049609. eCollection 2023.
The influence of the apolipoprotein E ε4 allele (APOE4) on brain microstructure of cognitively normal older adults remains incompletely understood, in part due to heterogeneity within study populations. In this study, we examined white-matter microstructural integrity in cognitively normal older adults as a function of APOE4 carrier status using conventional diffusion-tensor imaging (DTI) and the novel orthogonal-tensor decomposition (DT-DOME), accounting for the effects of age and sex. Age associations with white-matter microstructure did not significantly depend on APOE4 status, but did differ between sexes, emphasizing the importance of accounting for sex differences in APOE research. Moreover, we found the DT-DOME to be more sensitive than conventional DTI metrics to such age-related and sex effects, especially in crossing WM fiber regions, and suggest their use in further investigation of white matter microstructure across the life span in health and disease.
载脂蛋白Eε4等位基因（APOE4）对认知正常的老年人脑微观结构的影响尚未完全明确，部分原因是研究人群内部存在异质性。在本研究中，我们使用传统扩散张量成像（DTI）和新型正交张量分解（DT-DOME），考虑年龄和性别的影响，将认知正常的老年人白质微观结构完整性作为APOE4携带者状态的函数进行研究。白质微观结构与年龄的关联并不显著依赖于APOE4状态，但在性别之间存在差异，这强调了在APOE研究中考虑性别差异的重要性。此外，我们发现DT-DOME比传统DTI指标对这种与年龄相关和性别的影响更敏感，尤其是在交叉白质纤维区域，并建议在进一步研究健康和疾病状态下全生命周期的白质微观结构时使用它们。
