Shen Ting, Sheriff Samran, You Yuyi, Jiang Jiyang, Schulz Angela, Francis Heather, Mirzaei Mehdi, Saks Danit, Chitranshi Nitin, Gupta Veer, Singh Maria Fiatarone, Klistorner Alexander, Wen Wei, Sachdev Perminder, Gupta Vivek K, Graham Stuart L
Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Macquarie Medical School, Macquarie University, Sydney, NSW, Australia.
Aging Brain. 2022 Aug 22;2:100049. doi: 10.1016/j.nbas.2022.100049. eCollection 2022.
To examine the relationships of retinal structural (optical coherence tomography) and visual functional (multifocal visual evoked potentials, mfVEP) indices with neuropsychological and brain structural measurements in healthy older subjects. 95 participants (mean (SD) age 68.1 (9.0)) years were recruited in the Optic Nerve Decline and Cognitive Change (ONDCC) study in this observational clinical investigation. OCT was conducted for retinal nerve fibre layer (RNFL) and mfVEP for amplitude and latency measurements. Participants undertook neuropsychological tests for cognitive performance and MRI for volumetric evaluation of various brain regions. Generalised estimating equation models were used for association analysis (p < 0.05). The brain volumetric measures including total grey matter (GM), cortex, thalamus, hippocampal and fourth ventricular volumes were significantly associated with global and sectoral RNFL. RNFL thickness correlated with delayed recalls of California verbal learning test (CVLT) and Rey complex figure test (RCFT). The mfVEP amplitudes associated with cerebral white matter (WM) and cingulate GM volumes in MRI and CVLT, RCFT and trail making test outcomes. A significant association of mfVEP latency with logical memory delayed recall and thalamus volume was also observed. Our results suggested significant association of specific RNFL and mfVEP measures with distinctive brain region volumes and cognitive tests reflecting performance in memory, visuospatial and executive functional domains. These findings indicate that the mfVEP and RNFL measurements may parallel brain structural and neuropsychological measures in the older population.
在健康老年受试者中，研究视网膜结构（光学相干断层扫描）和视觉功能（多焦视觉诱发电位，mfVEP）指标与神经心理学及脑结构测量之间的关系。在这项观察性临床研究的视神经衰退与认知变化（ONDCC）研究中，招募了95名参与者（平均（标准差）年龄68.1（9.0）岁）。进行光学相干断层扫描以测量视网膜神经纤维层（RNFL），并进行多焦视觉诱发电位测量以获取振幅和潜伏期数据。参与者接受神经心理学测试以评估认知表现，并进行磁共振成像以对各个脑区进行体积评估。使用广义估计方程模型进行关联分析（p<0.05）。包括总灰质（GM）、皮质、丘脑、海马体和第四脑室体积在内的脑体积测量与整体及扇形RNFL显著相关。RNFL厚度与加利福尼亚言语学习测试（CVLT）和雷氏复杂图形测试（RCFT）的延迟回忆相关。多焦视觉诱发电位振幅与磁共振成像中的脑白质（WM）和扣带回GM体积以及CVLT、RCFT和连线测验结果相关。还观察到多焦视觉诱发电位潜伏期与逻辑记忆延迟回忆和丘脑体积之间存在显著关联。我们的结果表明，特定的RNFL和多焦视觉诱发电位测量与不同脑区体积以及反映记忆、视觉空间和执行功能领域表现的认知测试之间存在显著关联。这些发现表明，多焦视觉诱发电位和RNFL测量可能与老年人群的脑结构和神经心理学测量并行。
